Evidence map›Paper›PMID 27197180›Full record

ArticleCancer research2016

NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells.

Tara Srinivasan, Jewell Walters, Pengcheng Bu, Elaine Bich Than, Kuei-Ling Tung, Kai-Yuan Chen, Nicole Panarelli, Jeff Milsom, Leonard Augenlicht, Steven M Lipkin and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Notch signaling in cancers: mechanism and potential therapy.Frontiers in cell and developmental biology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease.Translational research : the journal of laboratory and clinical medicine · 2023
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Asymmetric Cell Division and Tumor Heterogeneity.Frontiers in cell and developmental biology · 2022
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Tara SrinivasanDepartment of Biomedical Engineering, Cornell University, Ithaca, New York.
Jewell WaltersDepartments of Medicine, Genetic Medicine Surgery and Pathology, Weill Cornell Medical College, New York, New York.
Pengcheng BuDepartment of Biomedical Engineering, Cornell University, Ithaca, New York. School of Electrical and Computer Engineering, Cornell University, Ithaca, New York.
Elaine Bich ThanDepartments of Medicine, Genetic Medicine Surgery and Pathology, Weill Cornell Medical College, New York, New York.
Kuei-Ling TungDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, New York.
Kai-Yuan ChenSchool of Electrical and Computer Engineering, Cornell University, Ithaca, New York.
Nicole PanarelliDepartments of Medicine, Genetic Medicine Surgery and Pathology, Weill Cornell Medical College, New York, New York.
Jeff MilsomDepartments of Medicine, Genetic Medicine Surgery and Pathology, Weill Cornell Medical College, New York, New York.
Leonard AugenlichtMedicine and Cell Biology, Albert Einstein College of Medicine, Bronx, New York.
Steven M LipkinDepartments of Medicine, Genetic Medicine Surgery and Pathology, Weill Cornell Medical College, New York, New York. xs37@duke.edu stl2012@med.cornell.edu.
Xiling ShenDepartment of Biomedical Engineering, Cornell University, Ithaca, New York. School of Electrical and Computer Engineering, Cornell University, Ithaca, New York. Department of Biomedical Engineering, Duke University, Durham, North Carolina. xs37@duke.edu stl2012@med.cornell.edu.
Cornell University · USAlbert Einstein College of Medicine · USDuke University · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Multi-scale modeling of asymmetric cell divisionR01GM095990 · NIGMS · CORNELL UNIVERSITY · PI SHEN, XILING · 2011 to 2015
$1.5M
Robustness of the Intestinal Stem Cell NicheR01GM114254 · NIGMS · DUKE UNIVERSITY · PI SHEN, XILING · 2015 to 2017
$918k
NCATS NIH HHS UL1 TR001414NIGMS NIH HHS R01 GM095990NIGMS NIH HHS R01 GM114254
6 · The paper itself

Abstract

Colorectal cancer cells with stem-like properties, referred to as colon cancer-initiating cells (CCIC), have high tumorigenic potential. While CCIC can differentiate to promote cellular heterogeneity, it remains unclear whether CCIC within a tumor contain distinct subpopulations. Here, we describe the co-existence of fast- and slow-cycling CCIC, which can undergo asymmetric division to generate each other, highlighting CCIC plasticity and interconvertibility. Fast-cycling CCIC express markers, such as LGR5 and CD133, rely on MYC for their proliferation, whereas slow-cycling CCIC express markers, such as BMI1 and hTERT, are independent of MYC. NOTCH signaling promotes asymmetric cell fate, regulating the balance between these two populations. Overall, our results illuminate the basis for CCIC heterogeneity and plasticity by defining a direct interconversion mechanism between slow- and fast-cycling CCIC. Cancer Res; 76(11); 3411-21. ©2016 AACR.

Indexed as

Cell DifferentiationAC133 AntigenAnimalsApoptosisBiomarkers, TumorCell ProliferationColonic NeoplasmsHumansImmunoenzyme TechniquesMiceMice, Inbred NODMice, SCIDNeoplastic Stem CellsPolycomb Repressive Complex 1Receptors, G-Protein-CoupledReceptors, NotchAC133 AntigenBiomarkers, TumorBMI1 protein, humanLGR5 protein, humanPolycomb Repressive Complex 1Receptors, G-Protein-CoupledReceptors, NotchTelomeraseTERT protein, human

Identifiers

PMID27197180
PMCPMC4891252
OpenAlexW2338169771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.