Evidence map›Paper›PMID 27196936›Full record

ReviewAntioxidants (Basel, Switzerland)2016

Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine.

Bryant C Nelson, Monique E Johnson, Marlon L Walker, Kathryn R Riley, Christopher M Sims

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Adverse effects and underlying mechanism of rare earth elements.Environmental health : a global access science source · 2025
    Pooled it
  2. Pooled it
  3. Multifactorial Role of Phytogenic CeOPlant-environment interactions (Hoboken, N.J.) · 2026
    Review
  4. A Neutrophil Membrane-Encapsulated Pd/hCeOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Carbon@CeORSC advances · 2026
    Article
  6. Review
  7. Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  8. Article
  9. Advanced Chitin Nanocrystals/CeOSmall (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bryant C NelsonMaterial Measurement Laboratory-Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. bryant.nelson@nist.gov.
Monique E JohnsonMaterial Measurement Laboratory-Chemical Sciences Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. monique.johnson@nist.gov.
Marlon L WalkerMaterial Measurement Laboratory-Materials Measurement Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. marlon.walker@nist.gov.
Kathryn R RileyMaterial Measurement Laboratory-Chemical Sciences Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. kathryn.riley@nist.gov.
Christopher M SimsMaterial Measurement Laboratory-Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. christopher.sims@nist.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the automobile industry. Researchers are now harnessing the catalytic repertoire of CNPs to develop potential new treatment modalities for both oxidative- and nitrosative-stress induced disorders and diseases. In order to reach the point where our experimental understanding of the antioxidant activity of CNPs can be translated into useful therapeutics in the clinic, it is necessary to evaluate the most current evidence that supports CNP antioxidant activity in biological systems. Accordingly, the aims of this review are three-fold: (1) To describe the putative reaction mechanisms and physicochemical surface properties that enable CNPs to both scavenge reactive oxygen species (ROS) and to act as antioxidant enzyme-like mimetics in solution; (2) To provide an overview, with commentary, regarding the most robust design and synthesis pathways for preparing CNPs with catalytic antioxidant activity; (3) To provide the reader with the most up-to-date in vitro and in vivo experimental evidence supporting the ROS-scavenging potential of CNPs in biology and medicine.

Indexed as

cerium oxide nanoparticlesenzyme mimeticsnanoceriareactive oxygen speciesredox-cycling

Identifiers

PMID27196936
PMCPMC4931536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.