SynthesisGut2017
Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis.
Synthesis in Gut, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Atlas of human gut-associated lymphoid tissue reveals immunomodulatory interactions of B cells.Science immunology · 2026Article
- Relationship between the appendix and ulcerative colitis: A new discovery.World journal of gastrointestinal endoscopy · 2026Review
- Flos sophorae immaturus exosome-like nanovesicles alleviate ulcerative colitis by attenuating intestinal oxidative stress and inflammation through activating Aryl hydrocarbon receptor via gut microbiota and tryptophan metabolism regulation.Journal of nanobiotechnology · 2026Article
- Evidence for genetic correlation between appendix and inflammatory bowel disease: A bidirectional Mendelian randomization study.PloS one · 2026Article
- Appendectomy Is Not Associated With a Milder Clinical Course of Ulcerative Colitis: A Nationwide Danish Population-Based Study.Alimentary pharmacology & therapeutics · 2025Article
- The Place of Appendicectomy in Inflammatory Bowel Disease-A Review.ANZ journal of surgery · 2025Review
- The Role of Environmental Factors Prior to Diagnosis on the Activity and Severity of Inflammatory Bowel Diseases-Results From the Prospective Population-Based Copenhagen Inflammatory Bowel Disease Inception Cohort.United European gastroenterology journal · 2025Article
- Cholangioscope-assisted ERAT for the diagnoses and treatment of ulcerative colitis with appendiceal orifice inflammation: a case report and a literature review.International journal of colorectal disease · 2025Review
- Organosilicone double-long-chain diquaternary ammonium salt acts as a biofilm scavenger to ameliorate colitis induced by dextran sulfate sodium salt.Frontiers in immunology · 2025Article
- Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies.Journal of Crohn's & colitis · 2024Review
- The appendix and ulcerative colitis - an unsolved connection.Nature reviews. Gastroenterology & hepatology · 2023Review
- Human intestinal B cells in inflammatory diseases.Nature reviews. Gastroenterology & hepatology · 2023Review
- Endoscopic retrograde appendicitis therapy in the management of chronic fecalith appendicitis in a patient with ulcerative colitis: The first human case report.Frontiers in immunology · 2022Article
- Inflammation of the appendix in ulcerative colitis - Does it have a predictive value?United European gastroenterology journal · 2021Article
- Treatment-refractory ulcerative colitis responsive to indigo naturalis.BMJ open gastroenterology · 2021Article
- Environmental factors associated with biological use and surgery in inflammatory bowel disease.Journal of gastroenterology and hepatology · 2021Article
- Appendectomy Is Associated With Alteration of Human Gut Bacterial and Fungal Communities.Frontiers in microbiology · 2021Article
- A link between appendectomy and gastrointestinal cancers: a large-scale population-based cohort study in Korea.Scientific reports · 2020Article
- Ulcerative colitis.Nature reviews. Disease primers · 2020Review
- Appendiceal Orifice Inflammation in Ulcerative Colitis Mimicking Mucosa-Associated Lymphoid Tissue Lymphoma in the Cecum.Case reports in gastrointestinal medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 10 institutions in 2 countries.
Funding
Abstract
objectivesEarly appendectomy is inversely associated with the development of UC. However, the impact of appendectomy on the clinical course of UC is controversial, generally favouring a milder disease course. We aim to describe the effect appendectomy has on the disease course of UC with focus on the timing of appendectomy in relation to UC diagnosis.
designUsing the National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease Genetics Consortium database of patients with UC, the risk of colectomy was compared between patients who did and did not undergo appendectomy. In addition, we performed a meta-analysis of studies that examined the association between appendectomy and colectomy.
results2980 patients with UC were initially included. 111 (4.4%) patients with UC had an appendectomy; of which 63 were performed prior to UC diagnosis and 48 after diagnosis. In multivariable analysis, appendectomy performed at any time was an independent risk factor for colectomy (OR 1.9, 95% CI 1.1 to 3.1), with appendectomy performed after UC diagnosis most strongly associated with colectomy (OR 2.2, 95% CI 1.1 to 4.5). An updated meta-analysis showed appendectomy performed either prior to or after UC diagnosis had no effect on colectomy rates.
conclusionsAppendectomy performed at any time in relation to UC diagnosis was not associated with a decrease in severity of disease. In fact, appendectomy after UC diagnosis may be associated with a higher risk of colectomy. These findings question the proposed use of appendectomy as treatment for UC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.