ReviewAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2017
The genetics of anxiety-related negative valence system traits.
Review in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Nature genetics · 2026Pooled it
- The Twin Study of Negative Valence Emotional Constructs.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2016Trial
- Genetic and Environmental Influences on Fear Learning and Generalization.Psychophysiology · 2025Article
- Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: a scoping review.Frontiers in human neuroscience · 2023Article
- A dimensional approach to functional movement disorders: Heresy or opportunity.Neuroscience and biobehavioral reviews · 2021Review
- Neonatal Brain Response to Deviant Auditory Stimuli and Relation to Maternal Trait Anxiety.The American journal of psychiatry · 2021Article
- Article
- Genetic and environmental influences on cortisol reactivity to a psychosocial stressor in adolescents and young adults.Psychoneuroendocrinology · 2021Article
- Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder.Translational psychiatry · 2020Article
- Genetic and environmental risk structure of internalizing psychopathology in youth.Depression and anxiety · 2020Article
- Fear-potentiated startle response as an endophenotype: Evaluating metrics and methods for genetic applications.Psychophysiology · 2019Article
- Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework.Progress in brain research · 2019Article
- Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity.Biological psychiatry · 2018Review
- Gender-specific association of functionalNeuropsychiatric disease and treatment · 2018Article
- Latent structure of negative valence measures in childhood.Depression and anxiety · 2017Article
- A Population-Based Twin Study of Childhood Irritability and Internalizing Syndromes.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Article
- The research domain criteria framework in drug discovery for neuropsychiatric diseases: focus on negative valence.Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
NIMH's Research Domain Criteria (RDoC) domain of negative valence systems (NVS) captures constructs of negative affect such as fear and distress traditionally subsumed under the various internalizing disorders. Through its aims to capture dimensional measures that cut across diagnostic categories and are linked to underlying neurobiological systems, a large number of phenotypic constructs have been proposed as potential research targets. Since "genes" represent a central "unit of analysis" in the RDoC matrix, it is important for studies going forward to apply what is known about the genetics of these phenotypes as well as fill in the gaps of existing knowledge. This article reviews the extant genetic epidemiological data (twin studies, heritability) and molecular genetic association findings for a broad range of putative NVS phenotypic measures. We find that scant genetic epidemiological data is available for experimentally derived measures such as attentional bias, peripheral physiology, or brain-based measures of threat response. The molecular genetic basis of NVS phenotypes is in its infancy, since most studies have focused on a small number of candidate genes selected for putative association to anxiety disorders (ADs). Thus, more research is required to provide a firm understanding of the genetic aspects of anxiety-related NVS constructs. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.