Evidence map›Paper›PMID 27196425›Full record

ArticlePloS one2016

Effects of High-Temperature-Pressure Polymerized Resin-Infiltrated Ceramic Networks on Oral Stem Cells.

Mathilde Tassin, Eric Bonte, Ludwig S Loison-Robert, Ali Nassif, Tsouria Berbar, Stéphane Le Goff, Ariane Berdal, Michael Sadoun, Benjamin P J Fournier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Mathilde TassinLaboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Cordeliers Research Center, 15 rue de l'école de médecine, Paris, F-75006, France; Paris-Descartes; Pierre and Marie Curie; Paris-Diderot Universities, Paris, F-75006, France.
Eric BonteFaculty of Dentistry, Paris Descartes University, Sorbonne Paris Cité, France.
Ludwig S Loison-RobertFaculty of Dentistry, Paris Descartes University, Sorbonne Paris Cité, France.
Ali NassifFaculty of Dentistry, Paris Descartes University, Sorbonne Paris Cité, France.
Tsouria BerbarLaboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Cordeliers Research Center, 15 rue de l'école de médecine, Paris, F-75006, France; Paris-Descartes; Pierre and Marie Curie; Paris-Diderot Universities, Paris, F-75006, France.
Stéphane Le GoffURB2i, Faculty of Dentistry, Paris Descartes University, Sorbonne Paris Cité, France.
Ariane BerdalLaboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Cordeliers Research Center, 15 rue de l'école de médecine, Paris, F-75006, France; Paris-Descartes; Pierre and Marie Curie; Paris-Diderot Universities, Paris, F-75006, France.
Michael SadounFaculty of Dentistry, Paris Descartes University, Sorbonne Paris Cité, France.
Benjamin P J FournierLaboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Cordeliers Research Center, 15 rue de l'école de médecine, Paris, F-75006, France; Paris-Descartes; Pierre and Marie Curie; Paris-Diderot Universities, Paris, F-75006, France.
Délégation Paris 5 · FRUniversité Paris Cité · FRCentre de Recherche des Cordeliers · FRDélégation Paris 7 · FRDescartes (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe development of CAD-CAM techniques called for new materials suited to this technique and offering a safe and sustainable clinical implementation. The infiltration of resin in a ceramic network under high pressure and high temperature defines a new class of hybrid materials, namely polymer infiltrated ceramics network (PICN), for this purpose which requires to be evaluated biologically. We used oral stem cells (gingival and pulpal) as an in vitro experimental model.

methodsFour biomaterials were grinded, immersed in a culture medium and deposed on stem cells from dental pulp (DPSC) and gingiva (GSC): Enamic (VITA®), Experimental Hybrid Material (EHM), EHM with initiator (EHMi) and polymerized Z100™ composite material (3M®). After 7 days of incubation; viability, apoptosis, proliferation, cytoskeleton, inflammatory response and morphology were evaluated in vitro.

resultsProliferation was insignificantly delayed by all the tested materials. Significant cytotoxicity was observed in presence of resin based composites (MTT assay), however no detectable apoptosis and some dead cells were detected like in PICN materials. Cell morphology, major cytoskeleton and extracellular matrix components were not altered. An intimate contact appeared between the materials and cells. CLINICAL SIGNIFICANCE: The three new tested biomaterials did not exhibit adverse effects on oral stem cells in our experimental conditions and may be an interesting alternative to ceramics or composite based CAD-CAM blocks.

Indexed as

AdipocytesApoptosisBiocompatible MaterialsCell DifferentiationCell ProliferationCell SeparationCell SurvivalCeramicsCulture MediaDental PulpFlow CytometryGingivaHot TemperatureHumansInflammationMicroscopy, Electron, ScanningBiocompatible MaterialsCulture MediaPhenolsulfonphthaleinPolymersResins, Synthetic

Identifiers

PMID27196425
PMCPMC4873200
OpenAlexW2398944526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.