ArticleEvolution; international journal of organic evolution2016
A universal mechanism generating clusters of differentiated loci during divergence-with-migration.
Article in Evolution; international journal of organic evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Article
- Article
- Two transects reveal remarkable variation in gene flow on opposite ends of a European toad hybrid zone.Heredity · 2023Article
- Ten years of demographic modelling of divergence and speciation in the sea.Evolutionary applications · 2023Article
- The role of recombination landscape in species hybridisation and speciation.Frontiers in plant science · 2023Review
- Genetic architecture of repeated phenotypic divergence in Littorina saxatilis ecotype evolution.Evolution; international journal of organic evolution · 2022Article
- Review
- Hybridization Dynamics and Extensive Introgression in the Daphnia longispina Species Complex: New Insights from a High-Quality Daphnia galeata Reference Genome.Genome biology and evolution · 2021Article
- Genetic variation for adaptive traits is associated with polymorphic inversions inEvolution letters · 2021Article
- Genomic divergence landscape in recurrently hybridizingEvolution letters · 2021Article
- Evolution of putative barrier loci at an intermediate stage of speciation with gene flow in campions (Silene).Molecular ecology · 2020Article
- The impact of global selection on local adaptation and reproductive isolation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Towards the completion of speciation: the evolution of reproductive isolation beyond the first barriers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Divergent Selection and Primary Gene Flow Shape Incipient Speciation of a Riparian Tree on Hawaii Island.Molecular biology and evolution · 2020Article
- Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes.Molecular ecology · 2019Article
- Clines on the seashore: The genomic architecture underlying rapid divergence in the face of gene flow.Evolution letters · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide patterns of genetic divergence reveal mechanisms of adaptation under gene flow. Empirical data show that divergence is mostly concentrated in narrow genomic regions. This pattern may arise because differentiated loci protect nearby mutations from gene flow, but recent theory suggests this mechanism is insufficient to explain the emergence of concentrated differentiation during biologically realistic timescales. Critically, earlier theory neglects an inevitable consequence of genetic drift: stochastic loss of local genomic divergence. Here, we demonstrate that the rate of stochastic loss of weak local differentiation increases with recombination distance to a strongly diverged locus and, above a critical recombination distance, local loss is faster than local "gain" of new differentiation. Under high migration and weak selection, this critical recombination distance is much smaller than the total recombination distance of the genomic region under selection. Consequently, divergence between populations increases by net gain of new differentiation within the critical recombination distance, resulting in tightly linked clusters of divergence. The mechanism responsible is the balance between stochastic loss and gain of weak local differentiation, a mechanism acting universally throughout the genome. Our results will help to explain empirical observations and lead to novel predictions regarding changes in genomic architectures during adaptive divergence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.