ArticlePloS one2016
ROS Involves the Fungicidal Actions of Thymol against Spores of Aspergillus flavus via the Induction of Nitric Oxide.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 96 citations in OpenAlex.
- Antifungal Activity of Natural Thymol: Advances on Molecular Mechanisms and Therapeutic Potential.Biomolecules · 2026Review
- Cadmium Toxicity inFoods (Basel, Switzerland) · 2025Article
- Thymol as a Potential Natural Antiemetic: Insights From In Vivo and In Silico Studies.Food science & nutrition · 2025Article
- The Role of Oxidative Stress in the Antifungal Activity of Two Mollusk Fractions on Resistant Fungal Strains.International journal of molecular sciences · 2025Article
- Exogenous Nitric Oxide Induces Pathogenicity ofJournal of fungi (Basel, Switzerland) · 2024Article
- Burn Wound Healing Activity of Hydroxyethylcellulose Gels with Different Water Extracts Obtained from Various Medicinal Plants inInternational journal of molecular sciences · 2024Article
- Disruption of Cell Membranes and Redox Homeostasis as an Antibacterial Mechanism of Dielectric Barrier Discharge Plasma againstInternational journal of molecular sciences · 2024Article
- Unveiling the mechanism of essential oil action against skin pathogens: from ancient wisdom to modern science.Archives of microbiology · 2024Review
- Nitric Oxide in Fungi: Production and Function.Journal of fungi (Basel, Switzerland) · 2024Review
- Efficacy of 2,4-Di-ACS omega · 2024Article
- In vitro and Quantitative and Structure Activity Relationship (QSAR) evaluation of the antifungal activity of terpenoid constituents of essential oils against Alternaria alternata and Fusarium oxysporumBiomedica : revista del Instituto Nacional de Salud · 2023Article
- Identification of Virulence Factors in EntomopathogenicMicroorganisms · 2023Article
- Estragole Inhibits Growth and Aflatoxin Biosynthesis ofMicrobiology spectrum · 2023Article
- Protection of postharvest grains from fungal spoilage by biogenic volatiles.Applied microbiology and biotechnology · 2023Review
- Intracellular production of reactive oxygen species and a DAF-FM-related compound in Aspergillus fumigatus in response to antifungal agent exposure.Scientific reports · 2022Article
- Biogenic Silver Nanoparticles Strategically Combined WithFrontiers in microbiology · 2022Article
- Investigation of Antifungal Mechanisms of Thymol in the Human Fungal Pathogen,Molecules (Basel, Switzerland) · 2021Article
- o-Vanillin, a promising antifungal agent, inhibits Aspergillus flavus by disrupting the integrity of cell walls and cell membranes.Applied microbiology and biotechnology · 2021Article
- Metabolomic analyses revealed multifaceted effects of hexanal on Aspergillus flavus growth.Applied microbiology and biotechnology · 2021Article
- The Pathogenesis ofPolish journal of microbiology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus flavus is a well-known pathogenic fungus for both crops and human beings. The acquisition of resistance to azoles by A. flavus is leading to more failures occurring in the prevention of infection by A. flavus. In this study, we found that thymol, one of the major chemical constituents of the essential oil of Monarda punctate, had efficient fungicidal activity against A. flavus and led to sporular lysis. Further studies indicated that thymol treatment induced the generation of both ROS and NO in spores, whereas NO accumulation was far later than ROS accumulation in response to thymol. By blocking ROS production with the inhibitors of NADPH oxidase, NO generation was also significantly inhibited in the presence of thymol, which indicated that ROS induced NO generation in A. flavus in response to thymol treatment. Moreover, the removal of either ROS or NO attenuated lysis and death of spores exposed to thymol. The addition of SNP (exogenous NO donor) eliminated the protective effects of the inhibitors of NADPH oxidase on thymol-induced lysis and death of spores. Taken together, it could be concluded that ROS is involved in spore death induced by thymol via the induction of NO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.