ArticleJournal of perinatology : official journal of the California Perinatal Association2016
Does hyperglycemia in hypernatremic preterm infants increase the risk of intraventricular hemorrhage?
Article in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Sodium Values During the First 10 Postnatal Days in Extremely-Low-Birth-Weight Infants and Long-Term Neurocognitive Outcomes: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- Association of hyperglycemia in extremely preterm infants with neurodevelopmental outcomes at 18 months of corrected age.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Management of Neonatal Hyperglycaemia in Sweden-A Survey Study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Risk factors for intraventricular hemorrhage in very low birth weight infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Review
- Effects of Total Parenteral Nutrition on Serum Osmolality and Patent Ductus Arteriosus.Cureus · 2024Article
- Thermoregulation, incubator humidity, and skincare practices in appropriate for gestational age ultra-low birth weight infants: need for more evidence.World journal of pediatrics : WJP · 2024Review
- Hypernatremia in Hyperglycemia: Clinical Features and Relationship to Fractional Changes in Body Water and Monovalent Cations during Its Development.Journal of clinical medicine · 2024Review
- A Higher Amount of Nutritional Intake as a Possible Cause of Hyperglycemia in Extremely Premature Infants in Parenteral and Enteral Nutrition at the Tertiary Neonatal Intensive Care Unit.Children (Basel, Switzerland) · 2023Article
- Risk factors for periventricular-intraventricular haemorrhage severity in preterm infants: a propensity score-matched analysis.BMC pediatrics · 2023Article
- Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022Review
- Impact of glucose metabolism on the developing brain.Frontiers in endocrinology · 2022Review
- Turkish Neonatal Society Guideline on the Diagnosis and Management of Germinal Matrix Hemorrhage-Intraventricular Hemorrhage and Related Complications.Turkish archives of pediatrics · 2021Article
- Chorioamnionitis Is a Risk Factor for Intraventricular Hemorrhage in Preterm Infants: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHypernatremia and hyperglycemia are highly prevalent in preterm infants during the first week after birth, and both can lead to hyperosmolarity and osmotic shifts. The objective is to determine whether hyperglycemia increases the risk of intraventricular hemorrhage (IVH) in hypernatremic preterm infants. STUDY
designSingle-center retrospective medical record review of 216 infants <1000 g birth weight and <29 weeks gestational age (admitted over a 9-year period) who had serum sodium levels and blood glucose levels monitored at least every 24 h and more frequently if indicated during the first 10 days after birth. Hyperglycemia was defined as persistently high blood glucose (usually >200 mg dl(-1)) treated with an insulin infusion. Hypernatremia was defined as a serum sodium level of ⩾150 mmol l(-1) on repeated measurements.
resultsOf the 216 infants studied, 76 (35%) developed hyperglycemia and 126 (58%) developed hypernatremia. IVH developed more frequently in infants with hyperglycemia (P=0.006, odds ratio (OR) 2.3, 95% confidence interval (CI) 1.3 to 4.1), in infants with hypernatremia (P=0.018, OR 2.0, 95% CI 1.2 to 3.5) and in infants with hypernatremia plus hyperglycemia (P=0.001, OR 3.2, 95% CI 1.6 to 6.4). Multivariate regression analysis confirmed the independent association of higher risk of IVH with the presence of hypernatremia plus hyperglycemia (P=0.015, OR 2.6, 95% CI 1.2 to 5.5) but not with hypernatremia or hyperglycemia alone.
conclusionHyperglycemia increases the risk of IVH in hypernatremic preterm infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.