ArticlePLoS genetics2016
Additive Expression of Consolidated Memory through Drosophila Mushroom Body Subsets.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Disruption of a selective vesicle pool upon retrograde amnesia dissociates memory at presynaptic terminals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Elevated serotonin receptor 2A signaling restores learning and memory in a Fragile X syndrome model.Scientific reports · 2026Article
- Octopamine receptors inFrontiers in molecular neuroscience · 2026Article
- Review
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Memory-like states created by the first ethanol experience are encoded into the Drosophila mushroom body learning and memory circuitry in an ethanol-specific manner.PLoS genetics · 2025Article
- Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.PLoS biology · 2024Article
- An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Anesthesia Resistant Memories in Drosophila, a Working Perspective.International journal of molecular sciences · 2022Review
- Sesamin Activates Nrf2/Cnc-Dependent Transcription in the Absence of Oxidative Stress inAntioxidants (Basel, Switzerland) · 2021Article
- Serotonin Signals Modulate Mushroom Body Output Neurons for Sustaining Water-Reward Long-Term Memory inFrontiers in cell and developmental biology · 2021Article
- Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila.PLoS genetics · 2020Article
- Concerted Actions of Octopamine and Dopamine Receptors Drive Olfactory Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Forgetting memories through distinct actin remodeling mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila.PLoS genetics · 2019Article
- Nuclear Transcriptomes of the Seven Neuronal Cell Types That Constitute theG3 (Bethesda, Md.) · 2019Article
- Drk-mediated signaling to Rho kinase is required for anesthesia-resistant memory inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Preferential distribution of nuclear MAPK signal in α/β core neurons during long-term memory consolidation in Drosophila.Protein & cell · 2017Article
- Long-term memory requires sequential protein synthesis in three subsets of mushroom body output neurons in Drosophila.Scientific reports · 2017Article
- Neural circuits for long-term water-reward memory processing in thirsty Drosophila.Nature communications · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associative olfactory memory in Drosophila has two components called labile anesthesia-sensitive memory and consolidated anesthesia-resistant memory (ARM). Mushroom body (MB) is a brain region critical for the olfactory memory and comprised of 2000 neurons that can be classified into αβ, α'β', and γ neurons. Previously we demonstrated that two parallel pathways mediated ARM consolidation: the serotonergic dorsal paired medial (DPM)-αβ neurons and the octopaminergic anterior paired lateral (APL)-α'β' neurons. This finding prompted us to ask how this composite ARM is retrieved. Here, we showed that blocking the output of αβ neurons and that of α'β' neurons each impaired ARM retrieval, and blocking both simultaneously had an additive effect. Knockdown of radish and octβ2R in αβ and α'β' neurons, respectively, impaired ARM. A combinatorial assay of radish mutant background rsh1 and neurotransmission blockade confirmed that ARM retrieved from α'β' neuron output is independent of radish. We identified MBON-β2β'2a and MBON-β'2mp as the MB output neurons downstream of αβ and α'β' neurons, respectively, whose glutamatergic transmissions also additively contribute to ARM retrieval. Finally, we showed that α'β' neurons could be functionally subdivided into α'β'm neurons required for ARM retrieval, and α'β'ap neurons required for ARM consolidation. Our work demonstrated that two parallel neural pathways mediating ARM consolidation in Drosophila MB additively contribute to ARM expression during retrieval.
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