ArticlePloS one2016
The Edinburgh Cognitive and Behavioural ALS Screen in a Chinese Amyotrophic Lateral Sclerosis Population.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What is the extent of reliability and validity evidence for screening tools for cognitive and behavioral change in people with ALS? A systematic review.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Pooled it
- The Effect of Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex on the Amyotrophic Lateral Sclerosis Patients With Cognitive Impairment: A Double-Blinded, Randomized, and Sham Control Trial.CNS neuroscience & therapeutics · 2025Trial
- Voxel-mirrored homotopic connectivity in upper motor neuron-dominant amyotrophic lateral sclerosis is associated with different spread directions.Brain imaging and behavior · 2026Article
- Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.Brain communications · 2026Article
- Review
- Unveiling structural damage of the corpus callosum in amyotrophic lateral sclerosis through diffusion tensor imaging and spread direction perspectives.Annals of medicine · 2025Observational
- The Impact of Bulbar and Upper Motor Neuron Involvement on Oculomotor Movement in Amyotrophic Lateral Sclerosis.Brain and behavior · 2025Article
- White matter integrity mediated the effect of plasma uric acid levels on cognitive function in ALS patients.Brain imaging and behavior · 2025Article
- Association between cardiac autonomic dysfunction, cognitive impairment, and survival in patients with amyotrophic lateral sclerosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- The experience of pain symptoms in patients with amyotrophic lateral sclerosis: a qualitative study.Scientific reports · 2025Article
- Association between apathy and caregiver burden in patients with amyotrophic lateral sclerosis: a cross-sectional study.BMJ open · 2024Article
- Smell loss is associated with cognitive impairment in amyotrophic lateral sclerosis patients.CNS neuroscience & therapeutics · 2024Article
- The role ofFrontiers in neuroscience · 2024Article
- Different patterns of structural network impairments in two amyotrophic lateral sclerosis subtypes driven byBrain communications · 2024Article
- Postural instability and lower extremity dysfunction in upper motor neuron-dominant amyotrophic lateral sclerosis.Frontiers in neurology · 2024Article
- Development and Validation of the Korean Version of the Edinburgh Cognitive and Behavioral Amyotrophic Lateral Sclerosis Screen (ECAS-K).Journal of clinical neurology (Seoul, Korea) · 2023Article
- Article
- Mutation spectrum of chinese amyotrophic lateral sclerosis patients with frontotemporal dementia.Orphanet journal of rare diseases · 2022Article
- Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis in a Tunisian Cohort.Neuro-ophthalmology (Aeolus Press) · 2022Article
- Neuroanatomical associations of the Edinburgh cognitive and Behavioural ALS screen (ECAS).Brain imaging and behavior · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe existing screening batteries assessing multiple neuropsychological functions are not specific to amyotrophic lateral sclerosis (ALS) patients and are limited to their physical dysfunctions, whereas category cognitive tests are too time-consuming to assess all the domains. The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was recently developed as a fast and easy cognitive screening tool specifically designed for patients. The purpose of the study was to validate the effectiveness of the Chinese version in Chinese ALS populations.
methodsEighty-four ALS patients and 84 age-, gender- and education-matched healthy controls were included in this cross-sectional study. All the participants took the ECAS, Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB). Primary caregivers of patients were interviewed for behavioural and psychiatric changes.
resultsSignificant differences were noted in language (p = 0.01), fluency, executive function, ALS-specific functions, and ECAS total score (p<0.01) between ALS patients and controls. The cut-off value of the total ECAS score was 81.92. Cognitive impairment was observed in 35.71% of patients, and 27.38% exhibited behavioural abnormalities. The ECAS total score had a medium correlation with education year. Memory was more easily impaired in the lower education group, whereas verbal fluency and language function tended to be preserved in the higher education group. The average time of ECAS was only 18 minutes.
conclusionThe Chinese version of the ECAS is the first screening battery assessing multiple neuropsychological functions specially designed for the ALS population in China, which provides an effective and rapid tool to screen cognitive and behavioural impairments.
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