Evidence map›Paper›PMID 27195696›Full record

Trial reportBritish journal of clinical pharmacology2016

The impact of a medication review with follow-up service on hospital admissions in aged polypharmacy patients.

Amaia Malet-Larrea, Estíbaliz Goyenechea, Victoria García-Cárdenas, Begoña Calvo, Jose M Arteche, Pedro Aranegui, Jose J Zubeldia, Miguel A Gastelurrutia, Fernando Martínez-Martínez, Shalom I Benrimoj

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05348538 (Feasibility Study of the Medication Review With Follow up Service for Patients With Polypharmacy in Swiss Community Pharmacies), which is not on this map. Cited by 27 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 7 pooled it
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05348538 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Feasibility Study of the Medication Review With Follow up Service for Patients With Polypharmacy in Swiss Community Pharmacies

TypeinterventionalSponsorCenter for Primary Care and Public Health (Unisante), University of Lausanne, SwitzerlandRan2023 to 2024Enrolled162ConditionsChronic DiseaseArmsMedication review with follow up or MaJ? for the acronym in french
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 7 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Amaia Malet-LarreaPharmaceutical Technology Department, University of the Basque Country, Vitoria-Gasteiz.
Estíbaliz GoyenecheaOfficial Pharmacist Association of Guipuzcoa, Donostia-San Sebastian, Spain.
Victoria García-CárdenasGraduate School of Health, University of Technology Sydney, Sydney, Australia.
Begoña CalvoPharmaceutical Technology Department, University of the Basque Country, Vitoria-Gasteiz.
Jose M ArtecheInternal Medicine Department, Donostia Hospital, Donostia-San Sebastian.
Pedro AraneguiInternal Medicine Department, Donostia Hospital, Donostia-San Sebastian.
Jose J ZubeldiaInternal Medicine Department, Donostia Hospital, Donostia-San Sebastian.
Miguel A GastelurrutiaPharmaceutical Care Research Group, University of Granada, Granada, Spain.
Fernando Martínez-MartínezPharmaceutical Care Research Group, University of Granada, Granada, Spain.
Shalom I BenrimojGraduate School of Health, University of Technology Sydney, Sydney, Australia.
Biogipuzkoa Health Research Institute · ESUniversidad de Granada · ESUniversity of Technology Sydney · AUUniversity of the Basque Country · ESMatia Fundazioa · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aims were to assess the impact of a medication review with follow-up (MRF) service provided in community pharmacy to aged polypharmacy patients on the number of medication-related hospital admissions and to estimate the effect on hospital costs.

methodsThis was a sub-analysis of a cluster randomized controlled trials carried out in 178 community pharmacies in Spain. Pharmacies in the intervention group (IG) provided a comprehensive medication review during 6 months. Pharmacists in the comparison group (CG) delivered usual care. For the purposes of this sub-analysis, an expert panel of three internal medicine specialists screened the hospitalizations occurring during the main study, in order to identify medication-related hospitalizations. Inter-rater reliability was measured using Fleiss's kappa. Hospital costs were calculated using diagnosis related groups.

resultsOne thousand four hundred and three patients were included in the main study and they had 83 hospitalizations. Forty-two hospitalizations (50.6%) were medicine-related, with a substantial level of agreement among the experts (kappa = 0.65, 95% CI 0.52, 0.78, P < 0.01). The number of medication-related hospitalizations was significantly lower in patients receiving MRF (IG 11, GC 31, P = 0.042). The probability of being hospitalized was 3.7 times higher in the CG (odds ratio 3.7, 95% CI 1.2, 11.3, P = 0.021). Costs for a medicine-related hospitalization were €6672. Medication-related hospitalization costs were lower for patients receiving MRF [IG: €94 (SD 917); CG: €301 (SD 2102); 95% CI 35.9, 378.0, P = 0.018].

conclusionMRF provided by community pharmacists might be an effective strategy to balance the assurance of the benefit from medications and the avoidance of medication-related hospitalizations in aged patients using polypharmacy.

Indexed as

PolypharmacyAgedCommunity Pharmacy ServicesDrug Utilization ReviewFemaleHealth Care CostsHospitalizationHumansMaleObserver VariationSpainageddrug utilization reviewhospitalizationpharmaceutical services

Identifiers

PMID27195696
PMCPMC5338122
OpenAlexW2388398465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.