ArticlePathogens and global health2016
Human coronavirus and severe acute respiratory infection in Southern Brazil.
Article in Pathogens and global health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- Cryptic Circulation and Co-Infections of Endemic Human Coronaviruses During the First Years of the COVID-19 Pandemic in Brazil.Advances in respiratory medicine · 2025Article
- Bayesian spatio-temporal modeling of severe acute respiratory syndrome in Brazil: A comparative analysis across pre-, during, and post-COVID-19 eras.Infectious Disease Modelling · 2025Article
- Global Epidemiology and Seasonality of Human Seasonal Coronaviruses: A Systematic Review.Open forum infectious diseases · 2024Article
- Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 Pandemic.Risk management and healthcare policy · 2023Article
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- Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes.Nature communications · 2022Article
- Establishment and evaluation of a quadruple quantitative real-time PCR assay for simultaneous detection of human coronavirus subtypes.Virology journal · 2022Article
- Clinical Study of Human Coronavirus NL63, OC43, 229E, HKU1 Infentions in Hospitalized Children from 2015 to 2020.Infection and drug resistance · 2022Article
- Systematic assessment of SARS-CoV-2 virus in wastewater, rivers and drinking water - A catchment-wide appraisal.The Science of the total environment · 2021Article
- Nucleoprotein-based ELISA for detection of SARS-COV-2 IgG antibodies: Could an old assay be suitable for serodiagnosis of the new coronavirus?Journal of virological methods · 2021Article
- Study of the Etiology of Acute Respiratory Infections in Children Under 5 Years at the Dr. Agostinho Neto Hospital, Praia, Santiago Island, Cabo Verde.Frontiers in pediatrics · 2021Article
- Nanoparticles-assisted delivery of antiviral-siRNA as inhalable treatment for human respiratory viruses: A candidate approach against SARS-COV-2.Nano select : open access · 2020Review
- Risk factors for disease progression in patients with mild to moderate coronavirus disease 2019-a multi-centre observational study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020Observational
- Propolis-induced exclusion of colloids: Possible new mechanism of biological action.Colloid and interface science communications · 2020Article
- COVID-19 and the use of immunomodulatory and biologic agents for severe cutaneous disease: An Australian/New Zealand consensus statement.The Australasian journal of dermatology · 2020Review
- SARS-CoV-2: fear versus data.International journal of antimicrobial agents · 2020Article
- The 2019 coronavirus: Learning curves, lessons, and the weakest link.International journal of clinical practice · 2020Article
- Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.Cell stress · 2020Article
- SARS-CoV-2 isolation from the first reported patients in Brazil and establishment of a coordinated task network.Memorias do Instituto Oswaldo Cruz · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human coronaviruses (HCoVs) are an important cause of respiratory tract infection and are responsible for causing the common cold in the general population. Thus, adequate surveillance of HCoV is essential. This study aimed to analyze the impact of HCoV infections and their relation to severe acute respiratory infection (SARI) in a hospitalized population in Southern Brazil. A cross-sectional study was conducted at a tertiary care hospital, and assessed inpatients under investigation for SARI by the hospital epidemiology department, and all patients who had nasopharyngeal aspirates collected from January 2012 to December 2013 to detect respiratory viruses (RVs). Viral infection was detected by multiplex reverse transcriptase polymerase chain reaction (RT-PCR), with primers specific to the subtypes HCoV-229E/NL63 and OC43/HKU1. The overall positivity rate was 58.8% (444/755), and HCoVs were detected in 7.6% (n = 34) of positive samples. Children below two years of age were most frequently affected (62%). Comorbidities were more likely to be associated with HCoVs than with other RVs. Immunosuppression was an independent risk factor for HCoV infection (OR = 3.5, 95% CI 1.6-7.6). Dyspnea was less frequently associated with HCoV infection (p < 0.001), and HCoV accounted for 6% of the SARI cases. Three patients infected with HCoV (9%) died from respiratory infection. HCoVs are important respiratory pathogens, especially in hospitalized children under 2 years of age and in immunosuppressed patients. They may account for a small proportion of SARI diagnoses, increased need for mechanical ventilation, intensive care unit admission, and death.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.