Evidence map›Paper›PMID 27195518›Full record

ArticleScientific reports2016

The mitogenome of a 35,000-year-old Homo sapiens from Europe supports a Palaeolithic back-migration to Africa.

M Hervella, E M Svensson, A Alberdi, T Günther, N Izagirre, A R Munters, S Alonso, M Ioana, F Ridiche, A Soficaru and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

M HervellaDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n. 48940 Leioa, Bizkaia, Spain.
E M SvenssonDepartment of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden.
A AlberdiNatural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
T GüntherDepartment of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden.
N IzagirreDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n. 48940 Leioa, Bizkaia, Spain.
A R MuntersDepartment of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden.
S AlonsoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n. 48940 Leioa, Bizkaia, Spain.
M IoanaHuman Genomics Laboratory, University of Medicine and Pharmacy of Craiova, Bvd. 1 Mai no 66, Romania.
F RidicheMuseum of Oltenia, History and Archaeology Department, Madona Dudu str. no. 14, Craiova, Romania.
A Soficaru"Fr. J. Rainer" Institute of Anthropology, Romanian Academy, Eroii Sanitari 8, P. O. Box 35-13, Romania.
M JakobssonDepartment of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden.
M G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
C de-la-RuaDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n. 48940 Leioa, Bizkaia, Spain.

Funding

European Research Council 310372
6 · The paper itself

Abstract

After the dispersal of modern humans (Homo sapiens) Out of Africa, hominins with a similar morphology to that of present-day humans initiated the gradual demographic expansion into Eurasia. The mitogenome (33-fold coverage) of the Peştera Muierii 1 individual (PM1) from Romania (35 ky cal BP) we present in this article corresponds fully to Homo sapiens, whilst exhibiting a mosaic of morphological features related to both modern humans and Neandertals. We have identified the PM1 mitogenome as a basal haplogroup U6*, not previously found in any ancient or present-day humans. The derived U6 haplotypes are predominantly found in present-day North-Western African populations. Concomitantly, those found in Europe have been attributed to recent gene-flow from North Africa. The presence of the basal haplogroup U6* in South East Europe (Romania) at 35 ky BP confirms a Eurasian origin of the U6 mitochondrial lineage. Consequently, we propose that the PM1 lineage is an offshoot to South East Europe that can be traced to the Early Upper Paleolithic back migration from Western Asia to North Africa, during which the U6 lineage diversified, until the emergence of the present-day U6 African lineages.

Indexed as

Gene FlowGenetics, PopulationGenome, MitochondrialHuman MigrationAfricaAnthropology, PhysicalEuropeGenes, MitochondrialHumansPhylogenyPhylogeography

Identifiers

PMID27195518
PMCPMC4872530

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.