ReviewIntractable & rare diseases research2016
Fever as an important resource for infectious diseases research.
Review in Intractable & rare diseases research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Clinical manifestations of COVID-19 in the general population: systematic review.Wiener klinische Wochenschrift · 2021Pooled it
- Appropriateness and Abuse of Antipyretics, Anti-Inflammatory Drugs and Antibiotics in Children and Adults.Antibiotics (Basel, Switzerland) · 2026Review
- Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The cycle of infectious fever - how it affects bacterial infections.Frontiers in cellular and infection microbiology · 2026Review
- Endotoxin's Impact on Organism: From Immune Activation to Tolerance and Beyond.Journal of clinical medicine · 2025Review
- Fever-like temperature impacts on Staphylococcus aureus and Pseudomonas aeruginosa interaction, physiology, and virulence both in vitro and in vivo.BMC biology · 2024Article
- Machine learning algorithms for the early detection of bloodstream infection in children with osteoarticular infections.Frontiers in pediatrics · 2024Article
- The Association Between Malignant Otitis Externa and Diabetes Mellitus in Africa: A Systematic Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Anemia and associated factors among internally displaced children at Debark refugee camp, North Gondar, Northwest Ethiopia.PloS one · 2023Article
- The application of wearable smart sensors for monitoring the vital signs of patients in epidemics: a systematic literature review.Journal of ambient intelligence and humanized computing · 2023Article
- Machine learning-based clinical decision support for infection risk prediction.Frontiers in medicine · 2023Article
- Role of nickel-regulated small RNA in modulation ofWorld journal of clinical cases · 2022Review
- The Relationship Between Colles' Fractures and Leukocytosis in the Emergency Department.Cureus · 2022Article
- Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.PLoS genetics · 2022Article
- Harnessing genetic resistance to rusts in wheat and integrated rust management methods to develop more durable resistant cultivars.Frontiers in plant science · 2022Review
- Article
- Evaluation of reticulorumen temperature boluses for the diagnosis of subclinical cases of bovine respiratory disease in feedlot cattle.Journal of animal science · 2021Article
- Cross-sectional study of parental knowledge, behaviour and anxiety in management of paediatric fever among German parents.BMJ open · 2021Article
- Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia.International journal of molecular sciences · 2021Review
- Let fever do its job: The meaning of fever in the pandemic era.Evolution, medicine, and public health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fever or pyrexia is a process where normal body temperature is raised over homeostasis conditions. Although many effects of fever over the immune system have been known for a long time, it has not been until recent studies when these effects have been evaluated in several infection processes. Results have been promising, as they have reported new ways of regulation, especially in RNA molecules. In light of these new studies, it seems important to start to evaluate the effects of pyrexia in current research efforts in host-pathogen interactions. Viruses and bacteria are responsible for different types of infectious diseases, and while it is of paramount importance to understand the mechanisms of infection, potential effects of fever on this process may have been overlooked. This is especially relevant because during the course of many infectious diseases the organism develops fever. Due to the lack of specific treatments for many of those afflictions, experimental evaluation in fever-like conditions can potentially bring new insights into the infection process and can ultimately help to develop treatments. The aim of this review is to present evidence that the temperature increase during fever affects the way the infection takes place, for both the pathogen and the host.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.