ReviewIntractable & rare diseases research2016
Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations.
Review in Intractable & rare diseases research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Efficacy of Rituximab on Refractory Organ Involvements in Granulomatosis with Polyangiitis: A Systematic Review of Case Reports.Current rheumatology reviews · 2024Pooled it
- Ocular Manifestations at Diagnosis of Anti-Neutrophil Cytoplasmic Anti-body-Associated Vasculitis: Clinical İmplications from a Retrospective Cohort.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- From Purpura to pulmonary hemorrhage: dermatological clues to systemic vasculitis - a case of granulomatosis with polyangiitis.Annals of medicine and surgery (2012) · 2026Article
- Subcarinal Mass: An Unusual Presentation of Granulomatosis With Polyangiitis.The American journal of case reports · 2026Review
- A Case of Eosinophilic Granulomatosis With Polyangiitis Presenting With Conjunctival Lesions During Treatment With IL-5 Inhibitors.Case reports in rheumatology · 2026Article
- A Red Eye in an Elderly Patient: A Case Report Highlighting the Importance of Urgent Diagnosis.Cureus · 2025Article
- Nasal Reconstruction in Granulomatosis with Polyangiitis Using an L-shaped Cartilage Strut Graft.Aesthetic plastic surgery · 2025Article
- A male patient with proptosis and palatal perforation: A diagnostic challenge.Radiology case reports · 2025Article
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- Violaceous Papules on Face.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Article
- Article
- Pediatric Presentations of Granulomatosis With Polyangiitis: A Double Case Study.Case reports in dermatological medicine · 2025Article
- A 79-Year-Old Woman With Worsening Headaches and Pachymeningeal Enhancement: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Diagnostic Dilemma: Investigating Respiratory Symptoms in a Middle-Aged Smoker.Clinical case reports · 2024Article
- Ocular Manifestation of Granulomatosis with Polyangiitis Presenting as Serous Retinal Detachment: A Case Report.Medicina (Kaunas, Lithuania) · 2024Article
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- Article
- Granulomatosis with Polyangiitis Discovered Because of Repeated Upper Eyelid Swelling.Medicina (Kaunas, Lithuania) · 2024Article
- An Autopsy Case of Renal-Limited Granulomatosis With Polyangiitis Presenting With Acute Renal Failure and Initial Delirium.Journal of clinical medicine research · 2024Article
- Ocular manifestations in ANCA-associated vasculitis: a comprehensive analysis from Chinese medical centers.Clinical rheumatology · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granulomatosis with polyangiitis (GPA) is a potentially lethal systemic disorder that is characterized by necrotizing vasculitis of small arteries and veins. The respiratory system is most commonly affected in limited forms of the disease, however upper and lower respiratory system, systemic vasculitis, and necrotizing glomerulonephritis are the characteristic components of the disease triad. The peak incidence is observed at 64-75 years of age, with a prevalence of 8-10 per million depending on geographic location. In this review we focus on the ocular manifestations of the disease which occur in nearly in one third of the patients. In addition we describe the neuro-ophthalmic complications which occur in up to half of cases. We also discuss the current systemic treatment options including corticosteroids, cyclophosphamide, azathioprine, and the available biologic response modifiers including rituximab. The disease remains difficult to diagnose due to the generalized symptomatic presentation of patients with GPA. As a result, several sets of diagnostic criteria have been developed which include clinical, serological, and histopathological findings to varying extents. Early diagnosis and multi-specialty collaboration among physicians is necessary to adequately manage the disease and the potential complications that may result from drugs used in the treatment of the disease. Despite recent advances, more research is necessary to prevent the high rates of mortality from the disease itself and from therapeutic side effects.
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