ArticleNeural plasticity2016
Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study.
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Cave adaptation drives coordinated transcriptional remodeling across diverse cell types in the brain of a teleost fish.bioRxiv : the preprint server for biology · 2026Article
- The Astroglia Syncytial Theory of Consciousness.International journal of molecular sciences · 2025Review
- Baicalin protects neurons from oxidative stress and apoptosis induced by glutamate excitotoxicity in HT-22 cells.Journal of veterinary science · 2025Article
- Extending Mathematical Frameworks to Investigate Neuronal Dynamics in the Presence of Microglial Ensheathment.Bulletin of mathematical biology · 2025Article
- ACognitive neurodynamics · 2024Article
- Neuron-Glial Interactions: Implications for Plasticity, Behavior, and Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence.Cognitive neurodynamics · 2024Article
- Radial astrocyte synchronization modulates the visual system during behavioral-state transitions.Neuron · 2023Article
- The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity.International journal of molecular sciences · 2023Review
- Article
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- The possible role of sodium leakage channel localization factor-1 in the pathophysiology and severity of autism spectrum disorders.Scientific reports · 2023Article
- Parameter Inference for an Astrocyte Model using Machine Learning Approaches.bioRxiv : the preprint server for biology · 2023Article
- Shining the Light on Astrocytic Ensembles.Cells · 2023Review
- Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics.Scientific reports · 2023Article
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Astrocytes Learn to Detect and Signal Deviations From Critical Brain Dynamics.Neural computation · 2022Article
- Hypergravity Attenuates Reactivity in Primary Murine Astrocytes.Biomedicines · 2022Article
- Astrocytic Glutamatergic Transmission and Its Implications in Neurodegenerative Disorders.Cells · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. Here, we focus on two experimentally well-identified gliotransmitter pathways, (i) modulations of synaptic release and (ii) postsynaptic slow inward currents mediated by glutamate released from astrocytes, and investigate their possible functional relevance on synaptic plasticity in a biophysical model of an astrocyte-regulated synapse. Our model predicts that both pathways could profoundly affect both short- and long-term plasticity. In particular, activity-dependent glutamate release from astrocytes could dramatically change spike-timing-dependent plasticity, turning potentiation into depression (and vice versa) for the same induction protocol.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.