ArticleBMJ open gastroenterology2016
Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series.
Article in BMJ open gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Hyperbaric oxygen therapy alters bowel perfusion and improves outcomes in patients with treatment-refractory ulcerative colitis: a prospective pilot trial.Journal of Crohn's & colitis · 2026Trial
- Is there a rationale for hyperbaric oxygen therapy in the patients with Post COVID syndrome? : A critical review.European archives of psychiatry and clinical neuroscience · 2024Review
- Use of vedolizumab combined with hyperbaric oxygen therapy to treat enteric fistula in Crohn's disease.Medical gas research · 2024Article
- The new insights of hyperbaric oxygen therapy: focus on inflammatory bowel disease.Precision clinical medicine · 2024Review
- Article
- Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics.Redox biology · 2022Review
- Hyperbaric Oxygen Therapy in Systemic Inflammatory Response Syndrome.Veterinary sciences · 2022Article
- Modern surgical strategies for perianal Crohn's disease.World journal of gastroenterology · 2020Review
- The Hyperoxic-Hypoxic Paradox.Biomolecules · 2020Review
- Ulcerative Colitis: Current and Emerging Treatment Strategies.Journal of clinical medicine · 2019Review
- Effect of oxygen-producing suture material on hypoxic colonic anastomoses in an experimental model.BJS open · 2019Article
- Contemporary Medical Management of Acute Severe Ulcerative Colitis.Inflammatory bowel diseases · 2019Review
- The role of hyperbaric oxygen therapy in inflammatory bowel disease: a narrative review.Medical gas researchReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperbaric oxygen (HBO) is used as part of treatment in a variety of clinical conditions. Its use in the treatment of ulcerative colitis has been reported in few clinical reports.
objectiveWe report the effect of HBO on refractory ulcerative colitis exploring one potential mechanism of action.
designA review of records of patients with refractory ulcerative colitis who received HBO was conducted. Clinical and histopathological scoring was utilised to evaluate the response to HBO therapy (HBOT).
resultsAll patients manifested clinical improvement by the 40th cycle of HBOT. The median number of stool frequency dropped from seven motions/day (range=3-20) to 1/day (range=0.5-3), which was significant (z=-4.6, p<0.001). None of the patients manifested persistent blood passage after HBOT (z=-3.2, p=0.002). The severity index significantly improved after HBOT (z=-4.97, p<0.001). Histologically, a significant reduction of the scores of activity was recorded accompanied by a significant increase in the proliferating cell nuclear antigen labelling index of the CD44 cells of the colonic mucosa (p=0.001).
conclusionsHBOT is effective in the setting of refractory ulcerative colitis. The described protocol is necessary for successful treatment. HBOT stimulates colonic stem cells to promote healing.
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