ArticleNutrition & metabolism2016
Elevated gamma-glutamyl transferase is associated with subclinical inflammation independent of cardiometabolic risk factors in an asymptomatic population: a cross-sectional study.
Article in Nutrition & metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Gamma-glutamyltransferase and risk of cardiovascular mortality: A dose-response meta-analysis of prospective cohort studies.PloS one · 2017Pooled it
- Considering serum alanine aminotransferase and gamma-glutamyltransferase levels together strengthen the prediction of impaired fasting glucose risk: a cross-sectional and longitudinal study.Scientific reports · 2021Trial
- A Hidden Indicator of Cardiovascular Health: Serum Gamma-Glutamyl Transferase in Focus.Journal of cardiovascular translational research · 2026Review
- Urine protein electrophoresis analysis in dogs with systemic inflammatory response syndrome.Journal of veterinary internal medicine · 2026Article
- Phenotypic Differences in Inflammatory, Metabolic, and Biochemical Biomarkers in Dogs with Osteoarthritis According to Body Condition and Sex.Animals : an open access journal from MDPI · 2026Article
- The associations of maternal liver biomarkers in different trimesters with birth weight outcomes.Scientific reports · 2026Article
- A nomogram for assessing the risk of MAFLD based on the albumin-to-gamma-glutamyl transferase ratio.European journal of medical research · 2025Article
- Effect of Nutraceutical Supplementation and Mediterranean Hypocaloric Diet on Calculated Steatosis Indices and Inflammation: Clinical and In Vitro Evidences.Molecular nutrition & food research · 2025Article
- Association between gamma-glutamyl transferase levels and the retinal age gap.Frontiers in physiology · 2025Article
- Genotypes of carboxypeptidase A1 and gamma-glutamyltransferase 1 may be useful tools for the diagnosis and the predictor of worrisome features of intraductal papillary mucinous neoplasm in Japan.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Gamma-glutamyl transferase and the risk of all-cause and disease-specific mortality in patients with diabetes: A nationwide cohort study.Journal of diabetes · 2024Article
- Association between liver enzymes and type 2 diabetes: a real-world study.Frontiers in endocrinology · 2024Article
- Serum Gamma Glutamyltransferase: A Biomarker for Identifying Postprandial Hypertriglyceridemia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- A novel nomogram to predict the overall survival of early-stage hepatocellular carcinoma patients following ablation therapy.Frontiers in oncology · 2024Article
- Investigating the relationship between liver enzymes and incidence of hypertension: A population-based cohort study in Kharameh, a city in the South of Iran.Health science reports · 2023Article
- Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study.BMC research notes · 2022Article
- Evaluation of dietary mycotoxin control strategies on nursery pig growth performance and blood measures.Translational animal science · 2022Article
- To explore association between gamma-glutamyl transferase and type 2 diabetes using a real-world study and mendelian randomization analysis.Frontiers in endocrinology · 2022Observational
- Risk prediction for new-onset atrial fibrillation using the Minnesota code electrocardiography classification system.International journal of cardiology. Heart & vasculature · 2021Article
- Association Between Sex-Specific Serum Gamma-Glutamyltransferase and Incidence of Hypertension in a Chinese Population Without Metabolic Syndrome: A Prospective Observational Study.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum Gamma-Glutamyl Transferase (GGT), a marker of oxidative stress, has been suggested to be independently associated with cardiovascular disease (CVD) events. We examined the association of serum GGT levels with the burden of subclinical inflammation across a spectrum of metabolic conditions.
methodsWe evaluated 5,446 asymptomatic subjects (43 ± 10 years, 78 % males) who had an employer-sponsored physical between 2008 and 2010. Highly sensitivity C-reactive protein (hsCRP) was measured as a marker of underlying systemic inflammation. A linear regression of GGT quartiles with log transformed hsCRP and a multivariate logistic regression of GGT quartiles with elevated hsCRP (≥3 mg/L) were performed.
resultsMedian GGT was 31 IU/l (IQR: 22-45 IU/l), 1025 (19 %) had hsCRP ≥ 3 mg/L. The median hsCRP increased with GGT quartiles (Q1: 0.9 mg/L, Q2: 1.1 mg/L, Q3: 1.4 mg/L, Q4: 1.6 mg/L, p < 0.001). Linear regression models showed GGT in the fourth quartile was associated with 0.45 mg/L (95 % CI 0.35, 0.54, p < 0.001) increase in log transformed hsCRP adjusting for risk factors. The Odds Ratio (OR) for an elevated hsCRP (≥3 mg/L) also increased with higher GGT quartiles; GGT Q2 1.44 (95 % CI 1.12, 1.85), GGT Q3 1.89 (95 % CI 1.45, 2.46), GGT Q4 2.22 (95 % CI 1.67, 2.95), compared to GGT Q1. The strength of association increased in the presence of and combination of metabolic conditions.
conclusionIn our cohort of asymptomatic individuals a higher serum GGT level was independently associated with increased burden of subclinical inflammation across metabolic states. These findings may explain GGT association with increased CVD risk.
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