ArticleGenetics2016
Heterozygote Advantage Is a Common Outcome of Adaptation in Saccharomyces cerevisiae.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Beyond two alleles: multiallelic genotypic selection and its estimation from time-series data.BMC genomics · 2026Article
- Protective association of theFrontiers in medicine · 2026Article
- Effects of inbreeding on balancing selection: insights from Fisher's geometric model.Genetics · 2025Article
- Article
- Reconciling theories of dominance with the relative rates of adaptive substitution on sex chromosomes and autosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Polymorphism and the Red Queen: the selective maintenance of allelic variation in a deteriorating environment.G3 (Bethesda, Md.) · 2024Article
- Enhancing xylose-fermentation capacity of engineered Saccharomyces cerevisiae by multistep evolutionary engineering in inhibitor-rich lignocellulose hydrolysate.FEMS yeast research · 2024Article
- Article
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- Overdominant and partially dominant mutations drive clonal adaptation in diploid Saccharomyces cerevisiae.Genetics · 2022Article
- The Ecology and Evolution of the Baker's YeastGenes · 2022Review
- Overdominant Mutations Restrict Adaptive Loss of Heterozygosity at Linked Loci.Genome biology and evolution · 2021Article
- Sex alters molecular evolution in diploid experimental populations of S. cerevisiae.Nature ecology & evolution · 2020Article
- Emergence of a floral colour polymorphism by pollinator-mediated overdominance.Nature communications · 2019Article
- Article
- Frequent ploidy changes in growing yeast cultures.Current genetics · 2018Review
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Increase in viability due to the accumulation of X chromosome mutations in Drosophila melanogaster males.Genetica · 2018Article
- Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation.Nature ecology & evolution · 2018Article
- Genome-Wide Screen forG3 (Bethesda, Md.) · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Adaptation in diploids is predicted to proceed via mutations that are at least partially dominant in fitness. Recently, we argued that many adaptive mutations might also be commonly overdominant in fitness. Natural (directional) selection acting on overdominant mutations should drive them into the population but then, instead of bringing them to fixation, should maintain them as balanced polymorphisms via heterozygote advantage. If true, this would make adaptive evolution in sexual diploids differ drastically from that of haploids. The validity of this prediction has not yet been tested experimentally. Here, we performed four replicate evolutionary experiments with diploid yeast populations (Saccharomyces cerevisiae) growing in glucose-limited continuous cultures. We sequenced 24 evolved clones and identified initial adaptive mutations in all four chemostats. The first adaptive mutations in all four chemostats were three copy number variations, all of which proved to be overdominant in fitness. The fact that fitness overdominant mutations were always the first step in independent adaptive walks supports the prediction that heterozygote advantage can arise as a common outcome of directional selection in diploids and demonstrates that overdominance of de novo adaptive mutations in diploids is not rare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.