ArticleGenetics2016
Epistasis and the Dynamics of Reversion in Molecular Evolution.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Narrowed host ranges do not constrain future host range expansion in RNA phage Φ6.Journal of virology · 2026Article
- Compensatory Evolution Following Deleterious Episodes of GC-biased Gene Conversion in Rodents.Molecular biology and evolution · 2025Article
- Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Contingency and Entrenchment of Drug-Resistance Mutations in HIV Viral Proteins.The journal of physical chemistry. B · 2022Article
- Shifts in amino acid preferences as proteins evolve: A synthesis of experimental and theoretical work.Protein science : a publication of the Protein Society · 2021Review
- ECNet is an evolutionary context-integrated deep learning framework for protein engineering.Nature communications · 2021Article
- The evolutionary origin of the universal distribution of mutation fitness effect.PLoS computational biology · 2021Article
- Senescence and entrenchment in evolution of amino acid sites.Nature communications · 2020Article
- Minimum epistasis interpolation for sequence-function relationships.Nature communications · 2020Article
- Evolution Rapidly Optimizes Stability and Aggregation in Lattice Proteins Despite Pervasive Landscape Valleys and Mazes.Genetics · 2020Article
- Targeted insertional mutagenesis libraries for deep domain insertion profiling.Nucleic acids research · 2020Article
- Article
- Disadvantages and benefits of evolved unicellularity versus multicellularity in budding yeast.Ecology and evolution · 2019Article
- Modular epistasis and the compensatory evolution of gene deletion mutants.PLoS genetics · 2019Article
- Competitive species interactions constrain abiotic adaptation in a bacterial soil community.Evolution letters · 2018Article
- Article
- Article
- Compensatory mutations and epistasis for protein function.Current opinion in structural biology · 2018Review
- Pervasive contingency and entrenchment in a billion years of Hsp90 evolution.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation.Genetics · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent studies of protein evolution contend that the longer an amino acid substitution is present at a site, the less likely it is to revert to the amino acid previously occupying that site. Here we study this phenomenon of decreasing reversion rates rigorously and in a much more general context. We show that, under weak mutation and for arbitrary fitness landscapes, reversion rates decrease with time for any site that is involved in at least one epistatic interaction. Specifically, we prove that, at stationarity, the hazard function of the distribution of waiting times until reversion is strictly decreasing for any such site. Thus, in the presence of epistasis, the longer a particular character has been absent from a site, the less likely the site will revert to its prior state. We also explore several examples of this general result, which share a common pattern whereby the probability of having reverted increases rapidly at short times to some substantial value before becoming almost flat after a few substitutions at other sites. This pattern indicates a characteristic tendency for reversion to occur either almost immediately after the initial substitution or only after a very long time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.