ArticleProceedings. Biological sciences2016
Major evolutionary transitions of life, metabolic scaling and the number and size of mitochondria and chloroplasts.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Carbon-to-ATP ratios across the kingdoms of life.iScience · 2026Article
- Decoding the Hot-Mitochondrion Paradox.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Organ-Specific Shifts in Aerobic and Anaerobic Metabolism Throughout Metamorphosis Into Adulthood in a Fully Aquatic Amphibian.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Codepoietic Generation of Meaningful Information in the Evolving Biosphere.Entropy (Basel, Switzerland) · 2025Article
- Changes in plasma concentration of cell-free DNA in response to physical activity.Archives of medical science : AMS · 2025Article
- Putting CRISPR-Cas system in action: a golden window for efficient and precise genome editing for crop improvement.GM crops & food · 2023Review
- Metabolic compatibility and the rarity of prokaryote endosymbioses.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transcriptomic analysis provides insights into molecular mechanisms of thermal physiology.BMC genomics · 2022Article
- β-cell mitochondria in diabetes mellitus: a missing puzzle piece in the generation of hPSC-derived pancreatic β-cells?Journal of translational medicine · 2022Review
- Energetic equivalence underpins the size structure of tree and phytoplankton communities.Nature communications · 2019Article
- The Evolution of Per-cell Organelle Number.Frontiers in cell and developmental biology · 2016Review
- Mitochondrial Dynamics during Development.Newborn (Clarksville, Md.)Article
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Authors and funding
3 authors.
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Abstract
We investigate the effects of trophic lifestyle and two types of major evolutionary transitions in individuality-the endosymbiotic acquisition of organelles and development of multicellularity-on organellar and cellular metabolism and allometry. We develop a quantitative framework linking the size and metabolic scaling of eukaryotic cells to the abundance, size and metabolic scaling of mitochondria and chloroplasts and analyse a newly compiled, unprecedented database representing unicellular and multicellular cells covering diverse phyla and tissues. Irrespective of cellularity, numbers and total volumes of mitochondria scale linearly with cell volume, whereas chloroplasts scale sublinearly and sizes of both organelles remain largely invariant with cell size. Our framework allows us to estimate the metabolic scaling exponents of organelles and cells. Photoautotrophic cells and organelles exhibit photosynthetic scaling exponents always less than one, whereas chemoheterotrophic cells and organelles have steeper respiratory scaling exponents close to one. Multicellularity has no discernible effect on the metabolic scaling of organelles and cells. In contrast, trophic lifestyle has a profound and uniform effect, and our results suggest that endosymbiosis fundamentally altered the metabolic scaling of free-living bacterial ancestors of mitochondria and chloroplasts, from steep ancestral scaling to a shallower scaling in their endosymbiotic descendants.
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