ArticleScientific reports2016
Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Penicillium-Derived Inhibitors ofScientifica · 2025Article
- Targeted discovery of polyketides with antioxidant activity through integrated omics and cocultivation strategies.Applied and environmental microbiology · 2024Article
- Medicinal Chemistry Strategies for the Modification of Bioactive Natural Products.Molecules (Basel, Switzerland) · 2024Review
- Anti-vibriosis bioactive molecules from Arctic Penicillium sp. Z2230.Bioresources and bioprocessing · 2023Article
- HarnessingJournal of natural products · 2022Review
- Chemical Constituents of the Deep-Sea-DerivedMarine drugs · 2021Article
- Anti-Food Allergic Compounds fromMarine drugs · 2021Article
- Endophytic3 Biotech · 2020Review
- Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides.Molecules (Basel, Switzerland) · 2017Review
- Farnesyl phenolic enantiomers as natural MTH1 inhibitors fromOncotarget · 2017Article
- 16-nor Limonoids from Harrisonia perforata as promising selective 11β-HSD1 inhibitors.Scientific reports · 2016Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two new phenone derivatives penicophenones A (1) and B (2), a new cyclic tetrapeptide penicopeptide A (3), and five known compounds were isolated from the culture broth of Penicillium commune, an endophytic fungus derived from Vitis vinifera. Compounds 1-3 were elucidated by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. The absolute configurations of 1 and 3 were determined by comparing its ECD with related molecules and modified Marfey's analysis, respectively. Penicophenone A (1) possesses a rare benzannulated 6,6-spiroketal moiety, which is a new member of the unusual structural class with peniphenone A as the representative. Compound 3 exhibited significant inhibition activities against 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in vitro and showed strong binding affinity to 11β-HSD1. Moreover, compound 3 treatments decreased the lipid droplet accumulation associate with the inhibition of 11β-HSD1 expression in differentiate-induced 3T3-L1 preadipocytes. Furthermore, the molecular docking demonstrated that compound 3 coordinated in the active site of 11β-HSD1 is essential for the ability of diminishing the enzyme activity.
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