Evidence map›Paper›PMID 27194570›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2016

Mean arterial pressure values calculated using seven different methods and their associations with target organ deterioration in a single-center study of 1878 individuals.

Theodore G Papaioannou, Athanase D Protogerou, Dimitrios Vrachatis, Giorgos Konstantonis, Evaggelia Aissopou, Antonis Argyris, Efthimia Nasothimiou, Elias J Gialafos, Marianna Karamanou, Dimitris Tousoulis and 1 more

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

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  16. Association between dietary antioxidant indices and hypertension among Chinese adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Theodore G PapaioannouUnits of Biomedical Engineering and Biostatistics, First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Athanase D ProtogerouCardiovascular Research Lab, First Department of Propaedeutic Internal Medicine, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios VrachatisUnits of Biomedical Engineering and Biostatistics, First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Giorgos KonstantonisCardiovascular Research Lab, First Department of Propaedeutic Internal Medicine, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Evaggelia AissopouCardiovascular Research Lab, First Department of Propaedeutic Internal Medicine, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Antonis ArgyrisCardiovascular Research Lab, First Department of Propaedeutic Internal Medicine, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Efthimia NasothimiouCardiovascular Research Lab, First Department of Propaedeutic Internal Medicine, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Elias J GialafosAiginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Marianna KaramanouUnits of Biomedical Engineering and Biostatistics, First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Dimitris TousoulisUnits of Biomedical Engineering and Biostatistics, First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Petros P SfikakisCardiovascular Research Lab, First Department of Propaedeutic Internal Medicine, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess the differences among seven different methods for the calculation of mean arterial pressure (MAP) and to identify the formula that provides MAP values that are more closely associated with target organ deterioration as expressed by the carotid cross-sectional area (CSA), carotid-to-femoral pulse-wave velocity (cf-PWV) and left ventricular mass (LVM). The study population consisted of 1878 subjects who underwent noninvasive cardiovascular risk assessment. Blood pressure (BP) was assessed in all subjects, and MAP was calculated by direct oscillometry and six different formulas. Carotid artery ultrasound imaging was performed in 1628 subjects. The CSA of the right and left common carotid artery (CCA) were calculated and used as surrogates of arterial wall mass and hypertrophy. Aortic stiffness was evaluated in 1763 subjects by measuring the cf-PWV. Finally, 218 subjects underwent echocardiographic examination for the assessment of LVM. Among the examined methods of MAP calculation, the formula MAP1=[diastolic BP]+0.412 × [pulse pressure] yielded the strongest correlations with the LVM, cf-PWV and CSA of the right and left CCA, even after adjusting for age and gender. The MAP calculation using the 0.412 was superior compared with the traditional formula that uses the 0.33 for the discrimination of subjects with left ventricular and carotid wall hypertrophy, as well as subjects with increased aortic stiffness. MAP estimated with the 0.412 is better correlated with target organ deterioration compared with other formulas. Future studies are needed to explore the accuracy of these formulas for MAP estimation compared with direct intra-arterial BP measurement.

Indexed as

AdultAgedArterial PressureBlood Flow VelocityBlood Pressure DeterminationCarotid ArteriesEchocardiographyFemaleHemodynamicsHumansMaleMiddle AgedPulsatile FlowPulse Wave AnalysisReproducibility of ResultsRisk Assessment

Identifiers

PMID27194570

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.