ArticleJournal of the Royal Society, Interface2016
Gradual conversion of cellular stress patterns into pre-stressed matrix architecture during in vitro tissue growth.
Article in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.Bioactive materials · 2026Article
- Mechanical Cell Interactions on Curved Interfaces.Bulletin of mathematical biology · 2025Article
- Twisted-plywood-like tissue formationPNAS nexus · 2024Article
- Acidic Osteoid Templates the Plywood Structure of Bone Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth.Science advances · 2023Article
- Emergent collective organization of bone cells in complex curvature fields.Nature communications · 2023Article
- A Tissue Engineering Acoustophoretic (TEA) Set-up for the Enhanced Osteogenic Differentiation of Murine Mesenchymal Stromal Cells (mMSCs).International journal of molecular sciences · 2022Article
- Hydrogel Swelling-Mediated Strain Induces Cell Alignment at Dentin Interfaces.ACS biomaterials science & engineering · 2022Article
- Laser Sintering Approaches for Bone Tissue Engineering.Polymers · 2022Review
- Force-Bioreactor for Assessing Pharmacological Therapies for Mechanobiological Targets.Frontiers in bioengineering and biotechnology · 2022Article
- Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix.PLoS computational biology · 2020Article
- Channeling Effect and Tissue Morphology in a Perfusion Bioreactor Imaged by X-Ray Microtomography.Tissue engineering and regenerative medicine · 2020Article
- Surface tension determines tissue shape and growth kinetics.Science advances · 2019Article
- Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Confocal laser scanning microscopy-a powerful tool in bone research.Wiener medizinische Wochenschrift (1946) · 2018Article
- Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts.Science advances · 2018Article
- Modeling the Effect of Curvature on the Collective Behavior of Cells Growing New Tissue.Biophysical journal · 2017Article
- The influence of curvature on three-dimensional mineralized matrix formation under static and perfused conditions: an in vitro bioreactor model.Journal of the Royal Society, Interface · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complex arrangement of the extracellular matrix (ECM) produced by cells during tissue growth, healing and remodelling is fundamental to tissue function. In connective tissues, it is still unclear how both cells and the ECM become and remain organized over length scales much larger than the distance between neighbouring cells. While cytoskeletal forces are essential for assembly and organization of the early ECM, how these processes lead to a highly organized ECM in tissues such as osteoid is not clear. To clarify the role of cellular tension for the development of these ordered fibril architectures, we used an in vitro model system, where pre-osteoblastic cells produced ECM-rich tissue inside channels with millimetre-sized triangular cross sections in ceramic scaffolds. Our results suggest a mechanical handshake between actively contracting cells and ECM fibrils: the build-up of a long-range organization of cells and the ECM enables a gradual conversion of cell-generated tension to pre-straining the ECM fibrils, which reduces the work cells have to generate to keep mature tissue under tension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.