ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Npas1+ Pallidal Neurons Target Striatal Projection Neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Distinct Contributions and Sensorimotor Encoding of PV and FoxP2 Neurons in the External Globus Pallidus during Perceptual Decision-making.Neuroscience bulletin · 2026Article
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Perineuronal Net and Inhibitory Synapse Remodeling on Striatal Fast-Spiking Interneurons by Chronic Alcohol Exposure.Biological psychiatry · 2026Article
- The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits.bioRxiv : the preprint server for biology · 2026Article
- How the dynamic interplay of cortico-basal ganglia-thalamic pathways shapes the time course of deliberation and commitment.PLoS computational biology · 2026Article
- Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity.Science advances · 2025Article
- Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates.Current biology : CB · 2025Article
- Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake.Alcohol (Fayetteville, N.Y.) · 2025Review
- Article
- Reciprocal projections between the globus pallidus externa and cortex span motor and nonmotor regions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Matrix-biased excitatory and inhibitory inputs to the striatum involving external segment of the globus pallidus.Frontiers in cellular neuroscience · 2025Article
- Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input.Cell reports · 2024Article
- CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making.bioRxiv : the preprint server for biology · 2024Article
- Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Synaptic Changes in Pallidostriatal Circuits Observed in the Parkinsonian Model Triggers Abnormal Beta Synchrony with Accurate Spatio-temporal Properties across the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
- Rethinking the external globus pallidus and information flow in cortico-basal ganglia-thalamic circuits.ArXiv · 2023Article
- Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease.Current opinion in neurobiology · 2023Review
- The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.Developmental biology · 2023Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
unlabelledCompelling evidence demonstrates that the external globus pallidus (GPe) plays a key role in processing sensorimotor information. An anatomical projection from the GPe to the dorsal striatum has been described for decades. However, the cellular target and functional impact of this projection remain unknown. Using cell-specific transgenic mice, modern monosynaptic tracing techniques, and optogenetics-based mapping, we discovered that GPe neurons provide inhibitory inputs to direct and indirect pathway striatal projection neurons (SPNs). Our results indicate that the GPe input to SPNs arises primarily from Npas1-expressing neurons and is strengthened in a chronic Parkinson's disease (PD) model. Alterations of the GPe-SPN input in a PD model argue for the critical position of this connection in regulating basal ganglia motor output and PD symptomatology. Finally, chemogenetic activation of Npas1-expressing GPe neurons suppresses motor output, arguing that strengthening of the GPe-SPN connection is maladaptive and may underlie the hypokinetic symptoms in PD. SIGNIFICANCE STATEMENT: An anatomical projection from the pallidum to the striatum has been described for decades, but little is known about its connectivity pattern. The authors dissect the presynaptic and postsynaptic neurons involved in this projection, and show its cell-specific remodeling and strengthening in parkinsonian mice. Chemogenetic activation of Npas1(+) pallidal neurons that give rise to the principal pallidostriatal projection increases the time that the mice spend motionless. This argues that maladaptive strengthening of this connection underlies the paucity of volitional movements, which is a hallmark of Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.