Evidence map›Paper›PMID 27194309›Full record

Trial reportThe American journal of clinical nutrition2016

Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes.

Tonja R Nansel, Leah M Lipsky, Aiyi Liu

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00999375 phase2completednot on this map

Cultivating Healthy Environments in Families With Type 1 Diabetes (CHEF)

TypeinterventionalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2009 to 2013Enrolled293ConditionsType I DiabetesArmsEducation, Problem Solving, Social Learning, Behavior Modification
NCT06818032 nacompletednot on this mapstarted 2025, after this paper: background citation

Acute Avocado Consumption on Postprandial Glycemic and Appetite/Satiety Responses

TypeinterventionalSponsorUniversity of Vermont Medical CenterRan2025 to 2026Enrolled30ConditionsHealthy, Healthy Volunteer, Healthy Volunteers, Healthy AdultArmsNegative control, Avocado, Fat and fiber addition
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.

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  18. Barriers to Type 1 Diabetes Adherence in Adolescents.Journal of clinical medicine · 2024
    Review
  19. Does minimed 780GEuropean journal of clinical nutrition · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Tonja R NanselHealth Behavior Branch and nanselt@mail.nih.gov.ORCID http://orcid.org/0000-0002-8298-7595
Leah M LipskyHealth Behavior Branch and.ORCID http://orcid.org/0000-0003-2645-4388
Aiyi LiuBiostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Center for Health and Learning · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Kassel · DE

Funding

Enhancing Carbohydrate Quality in Diabetes ManagementZIAHD008805 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI NANSEL, TONJA · 2009 to 2022
$4.4M
Statistical Methods for Evaluation of BiomarkersZIAHD008875 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LIU, AIYI · 2009 to 2025
$3.8M
6 · The paper itself

Abstract

backgroundDespite the centrality of nutrition in the management of type 1 diabetes, the association of diet quality and macronutrient distribution with glycemic control is ambiguous.

objectiveThis study examined longitudinally the association of dietary intake with multiple indicators of glycemic control in youth with type 1 diabetes participating in a behavioral nutrition intervention study.

designParticipants in a randomized clinical trial of a behavioral nutrition intervention [n = 136; mean ± SD age: 12.8 ± 2.6 y; glycated hemoglobin (HbA1c): 8.1% ± 1.0%; 69.1% using an insulin pump] completed 3-d diet records at baseline and months 3, 6, 9, 12, and 18; masked continuous glucose monitoring (CGM) data were obtained concurrently with the use of the Medtronic iPro CGM system. HbA1c was obtained every 3 mo; 1,5-anhydroglucitol was obtained every 6 mo. Linear mixed-effects regression models estimated associations of time-varying dietary intake variables with time-varying glycemic control indicators, controlling for age, height, weight, sex, Tanner stage, diabetes duration, regimen, frequency of blood glucose monitoring, physical activity, and treatment assignment.

resultsHbA1c was associated inversely with carbohydrate and natural sugar, and positively with protein and unsaturated fat. 1,5-Anhydroglucitol was associated positively with fiber intake and natural sugar. Greater glycemic control as indicated by ≥1 CGM variable was associated with higher Healthy Eating Index-2005, whole plant food density, fiber, carbohydrate, and natural sugar and lower glycemic index and unsaturated fat.

conclusionsBoth overall diet quality and macronutrient distribution were associated with more optimal glycemic control. Associations were more consistent for CGM variables obtained concurrently with dietary intake than for biomarkers of longer-term glycemic control. These findings suggest that glycemic control may be improved by increasing intake of high-fiber, low glycemic-index, carbohydrate-containing foods. This trial was registered at clinicaltrials.gov as NCT00999375.

Indexed as

Glycemic IndexAdolescentBlood GlucoseChildDeoxyglucoseDiabetes Mellitus, Type 1DietDietary CarbohydratesDietary Fats, UnsaturatedDietary FiberDietary ProteinsDiet RecordsFemaleGlycated HemoglobinHumansInsulin1,5-anhydroglucitolBlood GlucoseDeoxyglucoseDietary CarbohydratesDietary Fats, UnsaturatedDietary FiberDietary ProteinsGlycated HemoglobinInsulincontinuous glucose monitoringdiet qualityglycemic controltype 1 diabetesyouth

Identifiers

PMID27194309
PMCPMC4919526
OpenAlexW2398039275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.