ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2017
Effects of hyaluronic acid and tacrolimus on the prevention of perineural scar formation and on nerve regeneration after sciatic nerve repair in a rabbit model.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Application strategies of autologous and decellularized nerve grafts: Structural and functional recovery.Neural regeneration research · 2026Article
- Mechanistic Advancements and Translational Progress in Hyaluronic Acid-Based Scaffolds and Conduits for Peripheral Nerve Regeneration.Journal of functional biomaterials · 2025Review
- Neuromodulators can promote nerve regeneration and accelerate functional recovery after peripheral nerve injury: A systematic review.Journal of orthopaedics · 2024Review
- Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model.Journal of personalized medicine · 2023Review
- Nerve trunk healing and neuroma formation after nerve transection injury.Frontiers in neurology · 2023Review
- The effect of FK506 (tacrolimus) loaded with collagen membrane and fibrin glue on promotion of nerve regeneration in a rat sciatic nerve traction injury model.Maxillofacial plastic and reconstructive surgery · 2022Article
- A sciatic nerve gap-injury model in the rabbit.Journal of materials science. Materials in medicine · 2022Article
- A Rabbit Model for Peripheral Nerve Reconstruction Studies Avoiding Automutilation Behavior.Journal of brachial plexus and peripheral nerve injury · 2022Article
- Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring.Journal of clinical medicine · 2021Review
- Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair.Theranostics · 2021Article
- Promotion of Peripheral Nerve Regeneration by Stimulation of the Extracellular Signal-Regulated Kinase (ERK) Pathway.Anatomical record (Hoboken, N.J. : 2007) · 2019Review
- Controlled release of FK506 from micropatterned PLGA films: potential for application in peripheral nerve repair.Neural regeneration research · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeScar formation after injured peripheral nerve repair is a significant clinical problem because it prevents nerve regeneration. The aim of this study was to investigate and compare the effects of hyaluronic acid (HA) and tacrolimus (FK506) on peripheral nerve regeneration in rabbits after the drugs were topically applied at the site of nerve repair.
methodsThirty adult male European rabbits (Oryctolagus cuniculus), ranging in weight from 2.5 to 3 kg, were randomly assigned to three groups: the HA and FK506 groups comprised the experimental groups, while the saline group served as the control. At week 12, macroscopic and microscopic evaluations were performed and analyzed.
resultsIn general, the macroscopic evaluations (skin and muscle fascia closure and nerve adherence), microscopic evaluations (cellular components, scar tissue formation index, and histomorphological organization), and measurements of nerve diameter and gastrocnemius muscle wet weight demonstrated the positive effects of topical application of these pharmacological agents (HA and FK506); HA and FK506 prevented scar formation and enhanced nerve regeneration. No significant differences in the parameters described above were observed between the HA and FK506 groups (P > 0.05). However, significant differences were observed between both the HA and FK506 groups and the saline group (P < 0.05).
conclusionBased on our findings, topical application of HA and FK506 exhibits equally positive effects, preventing perineural scar formation and enhancing nerve regeneration after peripheral nerve repair.
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