ReviewChembiochem : a European journal of chemical biology2016
The Oxygen Dilemma: A Severe Challenge for the Application of Monooxygenases?
Review in Chembiochem : a European journal of chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 149 citations in OpenAlex.
- Article
- Computational rational design of unspecific peroxygenase for C-H oxidation.Science advances · 2026Article
- Optimising COMicrobial cell factories · 2025Article
- Catalytic Dioxygen Activation Using a Diketopiperazine and a Manganese Catalyst for Selective C(spJACS Au · 2025Article
- High hydrostatic pressure stimulates n-CCommunications biology · 2025Article
- Exploring the role of flavin-dependent monooxygenases in the biosynthesis of aromatic compounds.Biotechnology for biofuels and bioproducts · 2024Review
- The Role of Dioxygen in Microbial Bio-Oxygenation: Challenging Biochemistry, Illustrated by a Short History of a Long Misunderstood Enzyme.Microorganisms · 2024Review
- Expanding the catalytic landscape of metalloenzymes with lytic polysaccharide monooxygenases.Nature reviews. Chemistry · 2024Review
- Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane.Organic process research & development · 2023Article
- Photocatalytic Synthesis of Hydrogen Peroxide from Molecular Oxygen and Water.Topics in current chemistry (Cham) · 2023Review
- Light-driven biocatalytic oxidation.Chemical science · 2022Review
- Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development.ChemMedChem · 2022Review
- Aerobic Photobiocatalysis Enabled by Combining Core-Shell Nanophotoreactors and Native Enzymes.Journal of the American Chemical Society · 2022Article
- Catalytic and Spectroscopic Properties of the Halotolerant Soluble Methane Monooxygenase Reductase from Methylomonas methanica MC09.Chembiochem : a European journal of chemical biology · 2022Article
- Whole-cell screening of oxidative enzymes using genetically encoded sensors.Chemical science · 2021Article
- Recent developments in the use of peroxygenases - Exploring their high potential in selective oxyfunctionalisations.Biotechnology advances · 2021Review
- Hemoprotein Catalyzed Oxygenations: P450s, UPOs, and Progress toward Scalable Reactions.JACS Au · 2021Review
- Structural and biochemical studies enlighten the unspecific peroxygenase from Hypoxylon sp. EC38 as an efficient oxidative biocatalyst.ACS catalysis · 2021Article
- Functional Expression of Two Unusual Acidic Peroxygenases fromApplied and environmental microbiology · 2021Article
- Pilot-Scale Production of Peroxygenase fromOrganic process research & development · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monooxygenases are promising catalysts because they in principle enable the organic chemist to perform highly selective oxyfunctionalisation reactions that are otherwise difficult to achieve. For this, monooxygenases require reducing equivalents, to allow reductive activation of molecular oxygen at the enzymes' active sites. However, these reducing equivalents are often delivered to O2 either directly or via a reduced intermediate (uncoupling), yielding hazardous reactive oxygen species and wasting valuable reducing equivalents. The oxygen dilemma arises from monooxygenases' dependency on O2 and the undesired uncoupling reaction. With this contribution we hope to generate a general awareness of the oxygen dilemma and to discuss its nature and some promising solutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.