ReviewNature reviews. Disease primers2016
Primary hyperparathyroidism.
Review in Nature reviews. Disease primers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06288490 (A Single Arm Study Comparing Amorphous Calcium Carbonate), which is not on this map. Cited by 124 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Single Arm Study Comparing Amorphous Calcium Carbonate (ACC) Supplement Versus Commercially Available Crystalline Calcium Supplements (CCS) in the Management of Hypoparathyroidism
Who cites it
124 citing papers in PubMed, 3 syntheses or guidelines pooled it, 251 citations in OpenAlex.
- Primary hyperparathyroidism-induced acute pancreatitis in pregnancy: A systematic review with a diagnostic-treatment algorithm.World journal of gastroenterology · 2024Pooled it
- Guidelines for fracture risk assessment and management of osteoporosis in postmenopausal women and men above the age of 50 in Qatar.Archives of osteoporosis · 2024Guideline
- Risk of fractures in primary hyperparathyroidism: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Comparison of endoscopic versus focused parathyroidectomy in surgical management of single-gland primary hyperparathyroidism: a randomized clinical trial.Langenbeck's archives of surgery · 2024Trial
- The Economics of Intraoperative Parathyroid Hormone Monitoring for Parathyroid Surgery: A Scoping Review of Cost Analyses and Economic Evaluations.Laryngoscope investigative otolaryngology · 2026Review
- Beyond conventional maging: the diagnostic performance of [Annals of nuclear medicine · 2026Article
- Management of patients with hypoparathyroidism: a Delphi consensus analysis.Journal of endocrinological investigation · 2026Article
- A novel PTH1R missense variant in a patient with early-onset primary hyperparathyroidism.Bone reports · 2026Article
- The FGF23/α-Klotho Axis in Postmenopausal Osteoporosis: Associations with Bone Mineral Density and Diagnostic Discrimination.Journal of clinical medicine · 2026Article
- Increasing incidence and prevalence of biochemically confirmed primary hyperparathyroidism in Stockholm, 2006-2020.The Journal of clinical endocrinology and metabolism · 2026Article
- [Analysis of epidemiological indicators of parathyroid gland diseases in the Chuvash republic based on registry data].Problemy endokrinologii · 2026Article
- Comparing deep-learning, radiomics, and fusion models for parathyroid tumor classification using ultrasound: a multicenter retrospective study.Quantitative imaging in medicine and surgery · 2026Article
- Expression analysis of epithelial membrane protein 1 (EMP1) gene in kidney stone patients.International urology and nephrology · 2026Article
- Prevalence and determinants of secondary hyperparathyroidism: IMOS-2021.Scientific reports · 2026Article
- Is atypical parathyroid tumor a different clinical entity than parathyroid adenoma and carcinoma? A retrospective review of a large single-center case series.Updates in surgery · 2026Article
- Phosphate handling as a determinant of osteoporosis in primary hyperparathyroidism.Endocrine connections · 2026Article
- Elevated parathyroid hormone levels in normocalcemic patients after parathyroidectomy for primary hyperparathyroidism: what risk factors should be considered?BMC endocrine disorders · 2026Article
- Article
- Parsley, pints, and potions: unraveling patient errors in kidney stone care.World journal of urology · 2026Article
- Design of Nanostructured Enzyme Immobilized Platforms for Precise Diagnosis and Treatment of Endocrine Disease: An Updated Review.International journal of nanomedicine · 2026Review
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 5 countries.
Funding
Abstract
Primary hyperparathyroidism (PHPT) is a common disorder in which parathyroid hormone (PTH) is excessively secreted from one or more of the four parathyroid glands. A single benign parathyroid adenoma is the cause in most people. However, multiglandular disease is not rare and is typically seen in familial PHPT syndromes. The genetics of PHPT is usually monoclonal when a single gland is involved and polyclonal when multiglandular disease is present. The genes that have been implicated in PHPT include proto-oncogenes and tumour-suppressor genes. Hypercalcaemia is the biochemical hallmark of PHPT. Usually, the concentration of PTH is frankly increased but can remain within the normal range, which is abnormal in the setting of hypercalcaemia. Normocalcaemic PHPT, a variant in which the serum calcium level is persistently normal but PTH levels are increased in the absence of an obvious inciting stimulus, is now recognized. The clinical presentation of PHPT varies from asymptomatic disease (seen in countries where biochemical screening is routine) to classic symptomatic disease in which renal and/or skeletal complications are observed. Management guidelines have recently been revised to help the clinician to decide on the merits of a parathyroidectomy or a non-surgical course. This Primer covers these areas with particular attention to the epidemiology, clinical presentations, genetics, evaluation and guidelines for the management of PHPT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.