Evidence map›Paper›PMID 27194147›Full record

SynthesisNeuro-oncology2016

Reporting of patient-reported health-related quality of life in adults with diffuse low-grade glioma: a systematic review.

Daniel M Fountain, Dominic Allen, Alexis J Joannides, Dipankar Nandi, Thomas Santarius, Aswin Chari

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  3. Health-related quality of life in adults with low-grade gliomas: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Pooled it
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  6. Cancer-specific utility: clinical validation of the EORTC QLU-C10D in patients with glioblastoma.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
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  18. Health-related quality of life and distress in elderly vs. younger patients with high-grade glioma-results of a multicenter study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Daniel M FountainDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (D.M.F., A.J.J., T.S.); Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK (D.M.F, A.J.J, T.S); Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK (D.A, D.N, A.C); Department of Neurosurgery, Imperial College Healthcare NHS Trust, London, UK (D.A, D.N, A.C).
Dominic AllenDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (D.M.F., A.J.J., T.S.); Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK (D.M.F, A.J.J, T.S); Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK (D.A, D.N, A.C); Department of Neurosurgery, Imperial College Healthcare NHS Trust, London, UK (D.A, D.N, A.C).
Alexis J JoannidesDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (D.M.F., A.J.J., T.S.); Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK (D.M.F, A.J.J, T.S); Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK (D.A, D.N, A.C); Department of Neurosurgery, Imperial College Healthcare NHS Trust, London, UK (D.A, D.N, A.C).
Dipankar NandiDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (D.M.F., A.J.J., T.S.); Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK (D.M.F, A.J.J, T.S); Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK (D.A, D.N, A.C); Department of Neurosurgery, Imperial College Healthcare NHS Trust, London, UK (D.A, D.N, A.C).
Thomas SantariusDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (D.M.F., A.J.J., T.S.); Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK (D.M.F, A.J.J, T.S); Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK (D.A, D.N, A.C); Department of Neurosurgery, Imperial College Healthcare NHS Trust, London, UK (D.A, D.N, A.C).
Aswin ChariDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (D.M.F., A.J.J., T.S.); Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK (D.M.F, A.J.J, T.S); Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK (D.A, D.N, A.C); Department of Neurosurgery, Imperial College Healthcare NHS Trust, London, UK (D.A, D.N, A.C).
Cambridge University Hospitals NHS Foundation Trust · GBImperial College Healthcare NHS Trust · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatient-reported health-related quality of life (HRQoL) analysis can provide important information for managing the balance between treatment benefits and treatment-related adverse effects on quality of life (QoL). This systematic review sought to identify the range of HRQoL measures used for patients with diffuse hemispheric WHO grade II glioma (DLGG) and assess the quality of HRQoL reporting.

methodsThis systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Databases were searched for full-text English articles reporting HRQoL outcomes in adult patients with DLGG.

resultsEleven different QoL measures were used across the 26 included studies, none of which has been validated in patients with DLGG. Heterogeneity of study design prevented pooled analysis of data investigating the effect of interventions or establishing long-term HRQoL. Low rates of participation at baseline (mean: 64.0%) and high rates of subsequent dropout (2.1% per month) were identified. Five studies gave statistical methods to deal with missing data or provided evidence of clinical significance of HRQoL results.

conclusionsThe results demonstrate a paucity and heterogeneity of reporting of HRQoL in the DLGG literature, highlighting the need for a standardized assessment schedule and set of validated quality-of-life measures for future studies.

Indexed as

Quality of LifeAdultBrain NeoplasmsGliomaHumansdiffuse low-grade gliomagliomahealth-related quality of lifequality of life

Identifiers

PMID27194147
PMCPMC5063520
OpenAlexW2397520769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.