ReviewNature reviews. Cardiology2016
Vein graft failure: from pathophysiology to clinical outcomes.
Review in Nature reviews. Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis.BMJ (Clinical research ed.) · 2019Pooled it
- Concise Review: Patency of Small-Diameter Tissue-Engineered Vascular Grafts: A Meta-Analysis of Preclinical Trials.Stem cells translational medicine · 2019Pooled it
- Efficacy of dual antiplatelet therapy for three months versus 12 months after coronary artery bypass grafting: multicentre, double blinded, randomised controlled trial.BMJ (Clinical research ed.) · 2026Trial
- No-touch vein grafts in coronary artery bypass surgery: a registry-based randomized clinical trial.European heart journal · 2025Trial
- Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial.The Journal of thoracic and cardiovascular surgery · 2024Trial
- Stable Hemodynamics within "No-Touch" Saphenous Vein Graft.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2020Trial
- Aneurysmal degeneration of venous bypass from drug-eluting stent.Journal of vascular surgery cases and innovative techniques · 2026Article
- Murine Model of Venous Bypass Grafting to Study Determinants of Graft Patency.Current protocols · 2026Article
- Molecular Mechanisms of Intimal Hyperplasia in Saphenous Vein Grafts After Coronary Artery Bypass Grafting.Cells · 2026Review
- Tenascin-C Drives Inflammatory VSMC Phenotypic Switching Through NF-κB Signaling in Saphenous Vein Graft Restenosis.International journal of molecular sciences · 2026Article
- Long-term outcomes of venous graft preservation in a rat autologous transplant model.Scientific reports · 2026Article
- EHMT2 aggravates vascular remodeling via epigenetic inhibition of GADD45G.Experimental & molecular medicine · 2026Article
- Great Saphenous Vein Lumen: Intimal Openings.Brazilian journal of cardiovascular surgery · 2026Review
- Aspirin Responsiveness and Early Saphenous Vein Graft Occlusion After Coronary Artery Bypass Grafting: A CT Coronary Angiography Study.Medicina (Kaunas, Lithuania) · 2026Observational
- HDL-Adjusted Inflammatory Ratios and Sequential Graft Configuration are Associated with Mid-Term Saphenous Vein Graft Occlusion in a Post-CABG Angiography Cohort.Journal of inflammation research · 2026Article
- A Dual-Crosslinked Metallo-elastomer Platform for Architecture-Directed Vascular Remodeling.Advanced fiber materials · 2026Article
- Article
- Short- and mid-term clinical outcomes of harmonic scalpel-assisted no-touch technique of the saphenous vein grafts harvesting in coronary bypass grafting.Journal of cardiothoracic surgery · 2025Article
- Synthetic and Tissue-Engineered Vascular Grafts: Current Status, Emerging Technologies, and Clinical Prospects.Reviews in cardiovascular medicine · 2025Review
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside from balloon angioplasty, bypass graft surgery is the most commonly performed revascularization technique for occlusive arterial disease. Coronary artery bypass graft surgery is performed in patients with left main coronary artery disease and three-vessel coronary disease, whereas peripheral artery bypass graft surgery is used to treat patients with late-stage peripheral artery occlusive disease. The great saphenous veins are commonly used conduits for surgical revascularization; however, they are associated with a high failure rate. Therefore, preservation of vein graft patency is essential for long-term surgical success. With the exception of 'no-touch' techniques and lipid-lowering and antiplatelet (aspirin) therapy, no intervention has hitherto unequivocally proven to be clinically effective in preventing vein graft failure. In this Review, we describe both preclinical and clinical studies evaluating the pathophysiology underlying vein graft failure, and the latest therapeutic options to improve patency for both coronary and peripheral grafts.
Indexed as
Identifiers
27194091What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.