Evidence map›Paper›PMID 27193909›Full record

ArticleHuman nature (Hawthorne, N.Y.)2016

Gender Interacts with Opioid Receptor Polymorphism A118G and Serotonin Receptor Polymorphism -1438 A/G on Speed-Dating Success.

Karen Wu, Chuansheng Chen, Robert K Moyzis, Ellen Greenberger, Zhaoxia Yu

Abstract read
PubMed Publisher
In one paragraph

Article in Human nature (Hawthorne, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. 5-HTPharmacological reviews · 2025
    Review
  4. Article
  5. Article
  6. Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karen WuDepartment of Psychology and Social Behavior, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697, USA. karenw1@uci.edu.
Chuansheng ChenDepartment of Psychology and Social Behavior, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697, USA.
Robert K MoyzisDepartment of Biological Chemistry, College of Medicine, University of California, Irvine, CA, 92697, USA.
Ellen GreenbergerDepartment of Psychology and Social Behavior, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697, USA.
Zhaoxia YuDepartment of Statistics, University of California, Irvine, CA, 92697, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined an understudied but potentially important source of romantic attraction-genetics-using a speed-dating paradigm. The mu opioid receptor (OPRM1) polymorphism A118G (rs1799971) and the serotonin receptor (HTR2A) polymorphism -1438 A/G (rs6311) were studied because they have been implicated in social affiliation. Guided by the social role theory of mate selection and prior genetic evidence, we examined these polymorphisms' gender-specific associations with speed-dating success (i.e., date offers, mate desirability). A total of 262 single Asian Americans went on speed-dates with members of the opposite gender and completed interaction questionnaires about their partners. Consistent with our prediction, significant gender-by-genotype interactions were found for speed-dating success. Specifically, the minor variant of A118G (G-allele), which has been linked to submissiveness/social sensitivity, predicted greater speed-dating success for women, whereas the minor variant of -1438 A/G (G-allele), which has been linked to leadership/social dominance, predicted greater speed-dating success for men. For both polymorphisms, reverse "dampening" effects of minor variants were found for opposite-gender counterparts. These results support previous research on the importance of the opioid and serotonergic systems in social affiliation, indicating that their influence extends to dating success, with opposite, yet gender-norm consistent, effects for men and women.

Indexed as

Interpersonal RelationsAdultAsianFemaleHumansMalePolymorphism, GeneticReceptor, Serotonin, 5-HT2AReceptors, Opioid, muSex FactorsSexual BehaviorOPRM1 protein, humanReceptor, Serotonin, 5-HT2AReceptors, Opioid, muBehavioral geneticsHuman mate selectionOpioidSerotoninSpeed-dating

Identifiers

PMID27193909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.