Evidence map›Paper›PMID 27193781›Full record

ArticleStem cell reviews and reports2016

Transplantation of Human Adipose Mesenchymal Stem Cells in Non-Immunosuppressed GRMD Dogs is a Safe Procedure.

M V Pelatti, J P A Gomes, N M S Vieira, E Cangussu, V Landini, T Andrade, M Sartori, L Petrus, Mayana Zatz

Abstract read
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In one paragraph

Article in Stem cell reviews and reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Skeletal Muscle Regenerative Potential of Human MuStem Cells following Transplantation into Injured Mice Muscle.Molecular therapy : the journal of the American Society of Gene Therapy · 2018
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M V PelattiHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090.
J P A GomesHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090.
N M S VieiraHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090.
E CangussuHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090.
V LandiniHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090.
T AndradeHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090.
M SartoriHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090.
L PetrusHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090.
Mayana ZatzHuman Genome and Stem-cell Research Center, Institute of Biosciences, University of São Paulo, Rua do Matão, n.106 - Cidade Universitária, São Paulo, SP, Brasil, 05508-090. mayazatz@usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The possibility to treat Duchenne muscular dystrophy (DMD), a lethal X-linked disorder, through cell therapy with mesenchymal stromal cells (MSCs) has been widely investigated in different animal models. However, some crucial questions need to be addressed before starting human therapeutic trials, particularly regarding its use for genetic disorders. How safe is the procedure? Are there any side effects following mesenchymal stem cell transplantation? To address these questions for DMD the best model is the golden retriever muscular dystrophy dog (GRMD), which is the closest model to the human condition displaying a much longer lifespan than other models. Here we report the follow-up of 5 GRMD dogs, which were repeatedly transplanted with human adipose-derived mesenchymal stromal cells (hASC), derived from different donors. Xenogeneic cell transplantation, which was done without immunosuppression, was well tolerated in all animals with no apparent long-term adverse effect. In the present study, we show that repeated heterologous stem-cell injection is a safe procedure, which is fundamental before starting human clinical trials.

Indexed as

Adipose TissueAnimalsCells, CulturedCreatine KinaseDisease Models, AnimalDog DiseasesDogsFeasibility StudiesFemaleFollow-Up StudiesHumansImmunocompetenceMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMuscular Dystrophy, AnimalMuscular Dystrophy, DuchenneCreatine KinaseCell therapyGRMD dogsHuman multipotent mesenchymal stromal cellsMuscular dystrophyXenotransplantation

Identifiers

PMID27193781

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.