Evidence map›Paper›PMID 27193754›Full record

ArticlePaediatric and perinatal epidemiology2016

Birth Outcomes in a Prospective Pregnancy-Birth Cohort Study of Environmental Risk Factors in Kuwait: The TRACER Study.

Mohammad AlSeaidan, Rihab Al Wotayan, Costas A Christophi, Massouma Al-Makhseed, Yara Abu Awad, Feiby Nassan, Ayah Ahmed, Smitha Abraham, Robert Bruce Boley, Tamarra James-Todd and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Paediatric and perinatal epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Mohammad AlSeaidanDasman Diabetes Institute, Kuwait, Kuwait.
Rihab Al WotayanPrimary Health Care, Ministry of Health, Kuwait, Kuwait.
Costas A ChristophiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Massouma Al-MakhseedHakim Clinic, Kuwait, Kuwait.
Yara Abu AwadDasman Diabetes Institute, Kuwait, Kuwait.
Feiby NassanDasman Diabetes Institute, Kuwait, Kuwait.
Ayah AhmedDasman Diabetes Institute, Kuwait, Kuwait.
Smitha AbrahamDasman Diabetes Institute, Kuwait, Kuwait.
Robert Bruce BoleyDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Tamarra James-ToddDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Rosalind J WrightDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Douglas W DockeryDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Kazem BehbehaniDasman Diabetes Institute, Kuwait, Kuwait.
Harvard University · USDasman Diabetes Institute · KWMinistry of Health · KWKuwait University · KW

Funding

Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
NICHD NIH HHS K12 HD051959
6 · The paper itself

Abstract

backgroundRapid development and westernisation in Kuwait and other Gulf states have been accompanied by rising rates of obesity, diabetes, asthma, and other chronic conditions. Prenatal experiences and exposures may be important targets for intervention. We undertook a prospective pregnancy-birth cohort study in Kuwait, the TRansgenerational Assessment of Children's Environmental Risk (TRACER) Study, to examine prenatal risk factors for early childhood obesity. This article describes the methodology and results of follow-up through birth.

methodsWomen were recruited at antenatal clinical visits. Interviewers administered questionnaires during the pregnancy and collected and banked biological samples. Children are being followed up with quarterly maternal interviews, annual anthropometric measurements, and periodic collection of biosamples. Frequencies of birth outcomes (i.e. stillbirth, preterm birth, small and large for gestational age, and macrosomia) were calculated as a function of maternal characteristics and behaviours.

resultsTwo thousand four hundred seventy-eight women were enrolled, and 2254 women were followed to delivery. Overall, frequencies of stillbirth (0.6%), preterm birth (9.3%), and small for gestational age (7.4%) were comparable to other developed countries, but not strongly associated with maternal characteristics or behaviours. Macrosomia (6.1%) and large for gestational age (23.0%) were higher than expected and positively associated with pre-pregnancy maternal overweight/obesity.

conclusionsA large birth cohort has been established in Kuwait. The collected risk factors and banked biosamples will allow examination of the effects of prenatal exposures on the development of chronic disease in children. Initial results suggest that maternal overweight/obesity before pregnancy should be targeted to prevent macrosomia and its associated sequelae of childhood overweight/obesity.

Indexed as

AdultBirth WeightChronic DiseaseDiabetes, GestationalFemaleHumansInfantInfant, NewbornKuwaitMaleMaternal ExposurePediatric ObesityPregnancyPregnancy OutcomePremature BirthPrenatal CareBirth outcomesCohortKuwaitObesityPregnancy

Identifiers

PMID27193754
PMCPMC4899085
OpenAlexW2357327042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.