Evidence map›Paper›PMID 27193558›Full record

ArticleNature communications2016

Therapeutic surfactant-stripped frozen micelles.

Yumiao Zhang, Wentao Song, Jumin Geng, Upendra Chitgupi, Hande Unsal, Jasmin Federizon, Javid Rzayev, Dinesh K Sukumaran, Paschalis Alexandridis, Jonathan F Lovell

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Topical Drug Delivery of Concentrated Cabazitaxel in an α-Tocopherol and DMSO Solution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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  6. Review
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  15. Article
  16. Article
  17. Review
  18. Formulation of Poloxamers for Drug Delivery.Journal of functional biomaterials · 2018
    Review
  19. Article
  20. Conjugated polymer nanomaterials for theranostics.Acta pharmacologica Sinica · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yumiao ZhangDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Wentao SongDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Jumin GengDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Upendra ChitgupiDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Hande UnsalDepartment of Chemistry; University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Jasmin FederizonDepartment of Chemistry; University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Javid RzayevDepartment of Chemistry; University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Dinesh K SukumaranDepartment of Chemistry; University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Paschalis AlexandridisDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
University at Buffalo, State University of New York · US

Funding

Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
NIH HHS DP5 OD017898
6 · The paper itself

Abstract

Injectable hydrophobic drugs are typically dissolved in surfactants and non-aqueous solvents which can induce negative side-effects. Alternatives like 'top-down' fine milling of excipient-free injectable drug suspensions are not yet clinically viable and 'bottom-up' self-assembled delivery systems usually substitute one solubilizing excipient for another, bringing new issues to consider. Here, we show that Pluronic (Poloxamer) block copolymers are amenable to low-temperature processing to strip away all free and loosely bound surfactant, leaving behind concentrated, kinetically frozen drug micelles containing minimal solubilizing excipient. This approach was validated for phylloquinone, cyclosporine, testosterone undecanoate, cabazitaxel and seven other bioactive molecules, achieving sizes between 45 and 160 nm and drug to solubilizer molar ratios 2-3 orders of magnitude higher than current formulations. Hypertonic saline or co-loaded cargo was found to prevent aggregation in some cases. Use of surfactant-stripped micelles avoided potential risks associated with other injectable formulations. Mechanistic insights are elucidated and therapeutic dose responses are demonstrated.

Indexed as

Drug CarriersMicellesPoloxamerFreezingHydrophobic and Hydrophilic InteractionsSurface-Active AgentsDrug CarriersMicellesPoloxamerSurface-Active Agents

Identifiers

PMID27193558
PMCPMC4874033
OpenAlexW2398020563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.