ArticleNature communications2016
Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
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- Peeling Back the Layers of Lymph Gland Structure and Regulation.International journal of molecular sciences · 2022Review
- Intrinsic and Extrinsic Regulation of Hematopoiesis inMolecules and cells · 2022Review
- Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis.eLife · 2021Article
- A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host's blood cells.PLoS pathogens · 2021Article
- The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling.eLife · 2021Article
- Drosophila as a Model to Study Cellular Communication Between the Hematopoietic Niche and Blood Progenitors Under Homeostatic Conditions and in Response to an Immune Stress.Frontiers in immunology · 2021Review
- Article
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- Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors ineLife · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-renewal and differentiation of mammalian haematopoietic stem cells (HSCs) are controlled by a specialized microenvironment called 'the niche'. In the bone marrow, HSCs receive signals from both the endosteal and vascular niches. The posterior signalling centre (PSC) of the larval Drosophila haematopoietic organ, the lymph gland, regulates blood cell differentiation under normal conditions and also plays a key role in controlling haematopoiesis under immune challenge. Here we report that the Drosophila vascular system also contributes to the lymph gland homoeostasis. Vascular cells produce Slit that activates Robo receptors in the PSC. Robo activation controls proliferation and clustering of PSC cells by regulating Myc, and small GTPase and DE-cadherin activity, respectively. These findings reveal that signals from the vascular system contribute to regulating the rate of blood cell differentiation via the regulation of PSC morphology.
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