ArticleScientific reports2016
Black perithecial pigmentation in Fusarium species is due to the accumulation of 5-deoxybostrycoidin-based melanin.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 70 citations in OpenAlex.
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- Pigments with antimicrobial and cytotoxic activities from the coprophilous fungusRSC advances · 2025Article
- The Growth, Pathogenesis, and Secondary Metabolism ofJournal of fungi (Basel, Switzerland) · 2025Article
- The Endoplasmic Reticulum Membrane Protein Complex Is Important for Deoxynivalenol Production and the Virulence ofJournal of fungi (Basel, Switzerland) · 2025Article
- First-class - biosynthesis of 6-MSA and bostrycoidin type I polyketides inFrontiers in fungal biology · 2024Article
- A Prototype Method for the Detection and Recognition of Pigments in the Environment Based on Optical Property Simulation.Plants (Basel, Switzerland) · 2023Article
- Yeast recombinational cloning for heterologous biosynthesis of polyketides: a molecular microbiology laboratory module for undergraduate students.Journal of microbiology & biology education · 2023Article
- Hiding in plain sight: Genome-wide recombination and a dynamic accessory genome drive diversity inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Extracellular vesicles in phytopathogenic fungi.Extracellular vesicles and circulating nucleic acids · 2023Review
- Transcriptional Divergence Underpinning Sexual Development in the Fungal Class Sordariomycetes.mBio · 2022Article
- Fungal quinones: diversity, producers, and applications of quinones from Aspergillus, Penicillium, Talaromyces, Fusarium, and Arthrinium.Applied microbiology and biotechnology · 2021Review
- Diversity and antibacterial activity of fungal endophytes from Eucalyptus exserta.BMC microbiology · 2021Article
- Production and Selectivity of Key Fusarubins fromToxins · 2021Article
- Heterologous Expression of the Core Genes in the Complex Fusarubin Gene Cluster ofInternational journal of molecular sciences · 2020Article
- Infection cushions of Fusarium graminearum are fungal arsenals for wheat infection.Molecular plant pathology · 2020Article
- Pigment production by Fusarium solani BRM054066 and determination of antioxidant and anti-inflammatory properties.AMB Express · 2020Article
- Advances in linking polyketides and non-ribosomal peptides to their biosynthetic gene clusters in Fusarium.Current genetics · 2019Review
- Fungal Pigments and Their Prospects in Different Industries.Microorganisms · 2019Review
- Comparative Genomics and Transcriptomics During Sexual Development Gives Insight Into the Life History of the Cosmopolitan FungusFrontiers in microbiology · 2019Article
- Extracellular Vesicles From the Cotton PathogenFrontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosynthesis of the black perithecial pigment in the filamentous fungus Fusarium graminearum is dependent on the polyketide synthase PGL1 (oPKS3). A seven-membered PGL1 gene cluster was identified by over-expression of the cluster specific transcription factor pglR. Targeted gene replacement showed that PGL1, pglJ, pglM and pglV were essential for the production of the perithecial pigment. Over-expression of PGL1 resulted in the production of 6-O-demethyl-5-deoxybostrycoidin (1), 5-deoxybostrycoidin (2), and three novel compounds 5-deoxybostrycoidin anthrone (3), 6-O-demethyl-5-deoxybostrycoidin anthrone (4) and purpurfusarin (5). The novel dimeric bostrycoidin purpurfusarin (5) was found to inhibit the growth of Candida albicans with an IC50 of 8.0 +/- 1.9 μM. The results show that Fusarium species with black perithecia have a previously undescribed form of 5-deoxybostrycoidin based melanin in their fruiting bodies.
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