ArticleBMC evolutionary biology2016
Heme pathway evolution in kinetoplastid protists.
Article in BMC evolutionary biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code.BMC genomics · 2024Article
- Haptoglobin is dispensable for haemoglobin uptake byFrontiers in immunology · 2024Article
- Evolutionary analysis of globin domains from kinetoplastids.Archives of microbiology · 2022Article
- Sequence Analysis and Comparison of TCTP Proteins from Human Protozoan Parasites.Acta parasitologica · 2022Article
- Heterotrophic euglenid Rhabdomonas costata resembles its phototrophic relatives in many aspects of molecular and cell biology.Scientific reports · 2021Article
- Retracing Storage Polysaccharide Evolution in Stramenopila.Frontiers in plant science · 2021Article
- Iron and Heme Metabolism at the Leishmania-Host Interface.Trends in parasitology · 2020Review
- Article
- Comparative genomics of Leishmania (Mundinia).BMC genomics · 2019Article
- Lateral Acquisitions Repeatedly Remodel the Oxygen Detoxification Pathway in Diplomonads and Relatives.Genome biology and evolution · 2019Article
- Nuclear genome sequence of the plastid-lacking cryptomonad Goniomonas avonlea provides insights into the evolution of secondary plastids.BMC biology · 2018Article
- Genome sequencing reveals metabolic and cellular interdependence in an amoeba-kinetoplastid symbiosis.Scientific reports · 2017Article
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7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundKinetoplastea is a diverse protist lineage composed of several of the most successful parasites on Earth, organisms whose metabolisms have coevolved with those of the organisms they infect. Parasitic kinetoplastids have emerged from free-living, non-pathogenic ancestors on multiple occasions during the evolutionary history of the group. Interestingly, in both parasitic and free-living kinetoplastids, the heme pathway-a core metabolic pathway in a wide range of organisms-is incomplete or entirely absent. Indeed, Kinetoplastea investigated thus far seem to bypass the need for heme biosynthesis by acquiring heme or intermediate metabolites directly from their environment.
resultsHere we report the existence of a near-complete heme biosynthetic pathway in Perkinsela spp., kinetoplastids that live as obligate endosymbionts inside amoebozoans belonging to the genus Paramoeba/Neoparamoeba. We also use phylogenetic analysis to infer the evolution of the heme pathway in Kinetoplastea.
conclusionWe show that Perkinsela spp. is a deep-branching kinetoplastid lineage, and that lateral gene transfer has played a role in the evolution of heme biosynthesis in Perkinsela spp. and other Kinetoplastea. We also discuss the significance of the presence of seven of eight heme pathway genes in the Perkinsela genome as it relates to its endosymbiotic relationship with Paramoeba.
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