ReviewCurrent genetics2017
Persistence and drug tolerance in pathogenic yeast.
Review in Current genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Persister cells in human fungal pathogens.PLoS pathogens · 2025Review
- Low-level direct currents eradicate multi-drug-resistantChemical engineering journal (Lausanne, Switzerland : 1996) · 2025Article
- Article
- Adaptation Under Pressure: Resistance and Stress Response Interplay in ClinicalJournal of fungi (Basel, Switzerland) · 2025Article
- TOR regulates variability of protein synthesis rates.The EMBO journal · 2024Article
- Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance.PloS one · 2024Article
- Review
- Unveiling drug-tolerant and persister-like cells inFrontiers in cellular and infection microbiology · 2023Article
- Quiescence inAnnual review of genetics · 2022Review
- Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Aspects of Multicellularity inGenes · 2020Review
- Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy.Frontiers in cellular and infection microbiology · 2020Review
- Article
- Ssd1 and the cell wall integrity pathway promote entry, maintenance, and recovery from quiescence in budding yeast.Molecular biology of the cell · 2019Article
- Quiescence, an individual journey.Current genetics · 2019Review
- Targeting intrinsic cell death pathways to control fungal pathogens.Biochemical pharmacology · 2019Review
- Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal.Current genetics · 2019Review
- Multiple interfaces control activity of the Candida glabrata Pdr1 transcription factor mediating azole drug resistance.Current genetics · 2019Review
- Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation.eLife · 2019Article
- Whi2 is a conserved negative regulator of TORC1 in response to low amino acids.PLoS genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, we briefly summarize the current understanding of how fungal pathogens can persist antifungal treatment without heritable resistance mutations by forming tolerant persister cells. Fungal infections tolerant to antifungal treatment have become a major medical problem. One mechanism leading to drug recalcitrance is the formation of antifungal persister cells. These cells have wild-type genotype with the ability to survive exposure to antifungal agents due to changed membrane composition, upregulated stress response, and enhanced cell wall integrity. Knowledge of the mechanisms regulating entry and exit of the persister phenotype is limited, but it has recently been shown that the inhibition of the growth regulating TORC1 pathway induces fungal persistence. The phenotypic properties of persister cells and the involvement of the TORC1 pathway indicate that persister cells are quiescent in G0 of the cell cycle. This knowledge leads us to suggest that the identified shared drug-tolerance mechanisms of persister and quiescent cells may serve as a foundation for developing novel treatment strategies that are independent of growth mode against systemic fungal infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.