ArticleJournal of neuroinflammation2016
Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning.
Article in Journal of neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- A unique polygenic mouse model of obesity exhibits a distinct immunological profile that may offer protection against systemic inflammation, diabetes, and behavioral impairments.Frontiers in immunology · 2025Article
- Effects of a Functional Food Made withFoods (Basel, Switzerland) · 2024Article
- Neonatal overfeeding attenuates microgliosis and hippocampal damage in an infant rat model of pneumococcal meningitis.Frontiers in immunology · 2024Article
- Mechanisms of Tertiary Neurodegeneration after Neonatal Hypoxic-Ischemic Brain Damage.Pediatric medicine (Hong Kong, China) · 2022Article
- Microglial infiltration mediates cognitive dysfunction in rat models of hypothalamic obesityFrontiers in cellular neuroscience · 2022Article
- Roadbumps at the Crossroads of Integrating Behavioral andFrontiers in toxicology · 2022Review
- Mapping of Microglial Brain Region, Sex and Age Heterogeneity in Obesity.International journal of molecular sciences · 2021Review
- Glial remodeling enhances short-term memory performance in Wistar rats.Journal of neuroinflammation · 2020Article
- High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra.International journal of molecular sciences · 2019Article
- Early-life high-fat diet-induced obesity programs hippocampal development and cognitive functions via regulation of gut commensal Akkermansia muciniphila.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Review
- High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner.Neurobiology of aging · 2019Article
- Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats.Neurobiology of aging · 2019Article
- TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity.Journal of neuroinflammation · 2018Article
- Neurocognitive and Health Correlates of Overweight and Obesity among Ten-Year-Old Children Born Extremely Preterm.The Journal of pediatrics · 2018Observational
- Fasting and Fast Food Diet Play an Opposite Role in Mice Brain Aging.Molecular neurobiology · 2018Article
- Small litter size impairs spatial memory and increases anxiety- like behavior in a strain-dependent manner in male mice.Scientific reports · 2018Article
- Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function.Frontiers in neuroscience · 2018Review
- Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats.Frontiers in aging neuroscience · 2018Article
- Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system.Oncotarget · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity can lead to cognitive dysfunction including poor performance in memory tasks. However, poor memory is not seen in all obese humans and takes several months to develop in animal models, indicating the adult brain is relatively resistant to obesity's cognitive effects. We have seen that, in the rat, overfeeding for as little as 3 weeks in early life leads to lasting obesity and microglial priming in the hypothalamus. Here we hypothesized that microglial hyper-sensitivity in the neonatally overfed rats extends beyond the hypothalamus into memory-associated brain regions, resulting in cognitive deficits.
methodsWe tested this idea by manipulating Wistar rat litter sizes to suckle pups in litters of 4 (overfed) or 12 (control).
resultsNeonatally overfed rats had microgliosis in the hippocampus after only 14 days overfeeding, and this persisted into adulthood. These changes were coupled with poor performance in radial arm maze and novel object recognition tests relative to controls. In controls, the experience of the radial arm maze reduced cell proliferation in the dentate gyrus and neuron numbers in the CA3. The learning task also suppressed microglial number and density in hippocampus and retrosplenial cortex. Neonatally overfed brains had impaired sensitivity to learning, with no neuronal or cell proliferative effects and less effective microglial suppression.
conclusionsThus, early life overfeeding contributes to a long-term impairment in learning and memory with a likely role for microglia. These data may partially explain why some obese individuals display cognitive dysfunction and some do not, i.e. the early life dietary environment is likely to have a vital long-term contribution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.