Evidence map›Paper›PMID 27193167›Full record

ArticleHuman molecular genetics2016

Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress.

Song Lou, Victoria C Lepak, Lynn E Eberly, Brian Roth, Weina Cui, Xiao-Hong Zhu, Gülin Öz, Janet M Dubinsky

Open access · bronzeAbstract read
In one paragraph

Article in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. HSF1 and Its Role in Huntington's Disease Pathology.Advances in experimental medicine and biology · 2023
    Review
  10. Review
  11. Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  12. Zero Echo TimeMetabolites · 2021
    Article
  13. A Rationale for Hypoxic and Chemical Conditioning in Huntington's Disease.International journal of molecular sciences · 2021
    Review
  14. Review
  15. Article
  16. Review
  17. Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  18. Imaging Guidance for Therapeutic Delivery: The Dawn of Neuroenergetics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Song LouDepartment of Neuroscience.
Victoria C LepakDepartment of Neuroscience.
Lynn E EberlyDivision of Biostatistics, School of Public Health.
Brian RothDepartment of Neuroscience.
Weina CuiCenter for MR Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, MN, USA.
Xiao-Hong ZhuCenter for MR Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, MN, USA.
Gülin ÖzCenter for MR Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, MN, USA.
Janet M DubinskyDepartment of Neuroscience dubin001@umn.edu.
University of Minnesota Medical Center · US

Funding

NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Ultra High Field (16.4 Tesla) Animal MRI/MRS SystemS10RR025031 · NCRR · UNIVERSITY OF MINNESOTA · PI GARWOOD, MICHAEL · 2008 to 2008
$2.0M
NCRR NIH HHS S10 RR025031NIBIB NIH HHS P41 EB015894NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

In vivo evidence for brain mitochondrial dysfunction in animal models of Huntington disease (HD) is scarce. We applied the novel

Indexed as

AnimalsBrainCorpus StriatumDinitrophenolsDisease Models, AnimalHuntington DiseaseMagnetic Resonance ImagingMaleMiceMice, TransgenicMitochondriaNeostriatumOxidative PhosphorylationOxygen ConsumptionStress, PhysiologicalDinitrophenols

Identifiers

PMID27193167
PMCPMC5181641
OpenAlexW2403525352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.