ArticleMicrobial ecology2016
High Nutrient Concentration Can Induce Virulence Factor Expression and Cause Higher Virulence in an Environmentally Transmitted Pathogen.
Article in Microbial ecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- High association of COVID-19 severity with poor gut health score in Lebanese patients.PloS one · 2021Trial
- Association of ultra-processed food patterns with overweight and obesity in the German health interview and examination survey for children and adolescents (KiGGS): a longitudinal study.BMC public health · 2025Article
- SanA is an inner membrane protein mediatingMicrobiology spectrum · 2025Article
- Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes.Microbiome · 2025Review
- The emergence of neuroinvasiveFrontiers in cellular and infection microbiology · 2025Article
- Host range expansion ofFrontiers in microbiology · 2025Article
- Nutrient enrichment increases virulence in an opportunistic environmental pathogen, with greater effect at low bacterial doses.FEMS microbiology ecology · 2024Article
- Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis.Cellular and molecular life sciences : CMLS · 2022Article
- Rich resource environment of fish farms facilitates phenotypic variation and virulence in an opportunistic fish pathogen.Evolutionary applications · 2022Article
- Comparative Genomics Reveal the Animal-Associated Features of theFrontiers in microbiology · 2022Article
- Ultra-processed Foods and Cardiovascular Diseases: Potential Mechanisms of Action.Advances in nutrition (Bethesda, Md.) · 2021Review
- The roles of environmental variation and parasite survival in virulence-transmission relationships.Royal Society open science · 2021Review
- Evidence that the stress hormone cortisol regulates biofilm formation differently among Flavobacterium columnare isolates.Veterinary research · 2019Article
- Current understanding on the roles of gut microbiota in fish disease and immunity.Zoological research · 2019Review
- Necropsy-based Wild Fish Health Assessment.Journal of visualized experiments : JoVE · 2018Article
- How Temperature, Pond-Drying, and Nutrients Influence Parasite Infection and Pathology.EcoHealth · 2018Article
- Review
- Do fish get wasted? Assessing the influence of effluents on parasitic infection of wild fish.PeerJ · 2018Article
- Gliding Motility and Expression of Motility-Related Genes in Spreading and Non-spreading Colonies ofFrontiers in microbiology · 2018Article
- Higher resource level promotes virulence in an environmentally transmitted bacterial fish pathogen.Evolutionary applications · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmentally transmitted opportunistic pathogens shuttle between two substantially different environments: outside-host and within-host habitats. These environments differ from each other especially with respect to nutrient availability. Consequently, the pathogens are required to regulate their behavior in response to environmental cues in order to survive, but how nutrients control the virulence in opportunistic pathogens is still poorly understood. In this study, we examined how nutrient level in the outside-host environment affects the gene expression of putative virulence factors of the opportunistic fish pathogen Flavobacterium columnare. The impact of environmental nutrient concentration on bacterial virulence was explored by cultivating the bacteria in various nutrient conditions, measuring the gene expression of putative virulence factors with RT-qPCR and, finally, experimentally challenging rainbow trout (Oncorhynchus mykiss) fry with these bacteria. Our results show that increased environmental nutrient concentration can increase the expression of putative virulence genes, chondroitinase (cslA) and collagenase, in the outside-host environment and may lead to more rapid fish mortality. These findings address that the environmental nutrients may act as significant triggers of virulence gene expression and therefore contribute to the interaction between an environmentally transmitted opportunistic pathogen and its host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.