ArticleInternational ophthalmology2017
Reduced ocular surface disease index (OSDI) scores in patients with isotretinoin treatment.
Article in International ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The effect of topical insulin in the treatment of isotretinoin-associated dry eye disease in patients with acne vulgaris.International ophthalmology · 2026Article
- Highlighting Ophthalmic Adverse Effects Associated with Isotretinoin.Life (Basel, Switzerland) · 2026Review
- Comparison of early postoperative dry eye after KLEx and FS-LASIK: a contralateral eye study.BMC ophthalmology · 2026Article
- Anterior segment optical coherence tomography study of the cornea and tear film after systemic isotretinoin treatment in acne vulgaris.BMC ophthalmology · 2025Observational
- In vivo confocal microscopy provides evidence of corneal nerve damage and basal tear film reduction in patients treated with oral isotretinoin.Journal of translational medicine · 2025Article
- Ocular Surface Disease Index questionnaire in different languages.Medical hypothesis, discovery & innovation ophthalmology journal · 2024Review
- The Effect of Oral Isotretinoin Therapy on Meibomian Gland Characteristics in Patients with Acne Vulgaris.Ophthalmology and therapy · 2023Article
- A review on drug-induced dry eye disease.Indian journal of ophthalmology · 2023Review
- The effect of day-long mask wearing on non-invasive break-up time.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway.Investigative ophthalmology & visual science · 2022Article
- Instability of tear film and loss of meibomian glands in patients with acne vulgaris.Arquivos brasileiros de oftalmologia · 2022Article
- Validation of the Arabic version of the Ocular Surface Disease Index Questionnaire.International journal of ophthalmology · 2021Article
- Agreement and repeatability of objective systems for assessment of the tear film.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- Hyaluronan Regulates Eyelid and Meibomian Gland Morphogenesis.Investigative ophthalmology & visual science · 2018Article
- Assessments of the ocular surface and meibomian gland morphology in patients with treatment-naive acne vulgaris.Arquivos brasileiros de oftalmologiaArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the changes in ocular surface and functions of tear-film in patients treated with systemic isotretinoin, to assess diagnostic performance of ocular surface disease index (OSDI) test in the dry eye conditions in association with the use of isotretinoin, and to determine the correlation between all tear-film function tests, OSDI and the dose and duration of isotretinoin administration. One hundred and twenty eyes of 60 subjects treated with oral isotretinoin were enrolled. All patients underwent ophthalmic examination at the baseline and another examination during the course of treatment. Biomicroscopic ophthalmic examination of the meibomian glands, non-anesthetized Schirmer test, and tear film break-up time (BUT) were performed. Subjective ocular complaints were scored with an OSDI questionnaire. Average Schirmer scores were not significantly changed by isotretinoin treatment. There were significant differences in the average OSDI score, the average meibomian gland disease (MGD) grade and average BUT value of both eyes during the treatment compared with baseline values (p < 0.01). There was a statistically significant inverse correlation between MGD grade and BUT value. There was no significant correlation between BUT value, OSDI score, Schirmer score, MGD grade, the total and divided dose of isotretinoin and the duration of treatment. The follow-up time was 4.01 ± 1.3 months (range 1.5-6 months). Systemic isotretinoin treatment can cause alterations in the tear film and dry eye symptoms. The OSDI test can be used as a diagnostic test for patients receiving systemic isotretinoin treatment.
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