Evidence map›Paper›PMID 27193121›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2016

The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na(+) currents.

Renata Morais Ferreira Amorim, Alana Freitas Pires, Tiago Dos Santos-Nascimento, Benildo S Cavada, Kyria Santiago do Nascimento, João Batista Cajazeiras, José Henrique Leal-Cardoso, Mário Rogério Lima Mota, Ana Maria S Assreuy

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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Renata Morais Ferreira AmorimInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, CEP 60740-000, Fortaleza, CE, Brazil.
Alana Freitas PiresInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, CEP 60740-000, Fortaleza, CE, Brazil.
Tiago Dos Santos-NascimentoInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, CEP 60740-000, Fortaleza, CE, Brazil.
Benildo S CavadaLaboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Campus do Pici, s/n; Bloco 907, CEP 60455-970, Fortaleza, CE, Brazil.
Kyria Santiago do NascimentoLaboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Campus do Pici, s/n; Bloco 907, CEP 60455-970, Fortaleza, CE, Brazil.
João Batista CajazeirasLaboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Campus do Pici, s/n; Bloco 907, CEP 60455-970, Fortaleza, CE, Brazil.
José Henrique Leal-CardosoInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, CEP 60740-000, Fortaleza, CE, Brazil.
Mário Rogério Lima MotaInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, CEP 60740-000, Fortaleza, CE, Brazil.
Ana Maria S AssreuyInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, CEP 60740-000, Fortaleza, CE, Brazil. anassreuy@gmail.com.
Universidade Estadual do Ceará · BRUniversidade Federal do Ceará · BRCentro de Estudos em Psicologia da Saúde · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE AND

designSodium channels are highly expressed in nociceptive sensory neurons during hypernociceptive conditions. Based on the presence of a glycosidic portion in the sodium channel β subunit associated to the antinociceptive effect of leguminous lectins via lectin domain, this study investigated the antinociceptive activity of the lectin isolated from Lonchocarpus araripensis seeds (LAL) in mice behavioral models and in NaV current in the nociceptor of rat dorsal root ganglion (DRG). MATERIAL/

methodsLAL antinociceptive activity and the participation of opioid system, lectin domain and sodium channels were evaluated in Swiss mice models of nociception (formalin, capsaicin, hot plate, tail flick, von Frey) and in primary cultures of Wistar rats neurons of DRG (patch clamp).

resultsLAL presented inhibitory effects in the nociception induced by chemical and mechanical, but not by thermal stimuli and reduced total Na(+) current. LAL activity was inhibited by the lectin association with its binding sugar N-acethyl-glucosamine.

conclusionLAL inhibits peripheral hypernociception by mechanisms that involve the lectin domain, inflammatory mediators and Na(+) channels. The innovative inhibitory action of leguminous lectins on NaV current brings new insights for the investigation of sodium channels role in nociception.

Indexed as

AnalgesicsFabaceaeLectinsAnimalsCapsaicinFormaldehydeGanglia, SpinalHot TemperatureMaleMiceNeuronsNociceptionPainPhysical StimulationRats, WistarSeedsAnalgesicsCapsaicinFormaldehydeLectinsSodium ChannelsAntinociceptionInflammatory painLonchocarpus araripensisProteinSodium current

Identifiers

PMID27193121
OpenAlexW2402176979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.