ArticleJournal of endocrinological investigation2016
Masked hypertension in newly diagnosed hypothyroidism: a pilot study.
Article in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Impact of thyroid disorders on flow-mediated dilation: a systematic review and meta-analysis.Journal of endocrinological investigation · 2026Pooled it
- Diagnostic performance of clinic and home blood pressure measurements compared with ambulatory blood pressure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Individual and joint associations of modifiable metabolic status and lifestyle with kidney stones among sedentary population: insights from a nationally representative dataset.International journal of surgery (London, England) · 2026Article
- Hypothyroidism: playing the cardiometabolic risk concerto.Thyroid research · 2025Review
- Circulating miR-206, miR-181b, and miR-21 as promising biomarkers in hypothyroidism and their relationship to related hyperlipidemia and hepatic steatosis.Frontiers in molecular biosciences · 2024Article
- Hypertension in Thyroid Disorders.Frontiers in endocrinology · 2019Review
- Association between thyroid abnormalities and hypertension among hospitalized US patients: data from the National Inpatient Sample.Cardiovascular endocrinology & metabolism · 2018Article
- Effect of Levothyroxine on Blood Pressure in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2018Article
- Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report.Journal of endocrinological investigation · 2017Review
- Physical performance in newly diagnosed hypothyroidism: a pilot study.Journal of endocrinological investigation · 2017Article
- Role of levothyroxine and vitamin E supplementation in the treatment of oxidative stress-induced injury and apoptosis of myocardial cells in hypothyroid rats.Journal of endocrinological investigation · 2017Article
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Authors and funding
11 authors at 1 institution in 1 country.
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Abstract
purposeMasked hypertension (MH) is the association of normal office blood pressure (BP) with high ambulatory or home BP. This condition is associated with increased cardiovascular target organ damage, as true hypertension. Because the relation with hypothyroidism is controversial, we investigated it in a pilot longitudinal and controlled study.
methodsWe consecutively enrolled 64 newly diagnosed hypothyroid patients, 38 subclinical (s-HYPO), and 26 overt (o-HYPO). The control group consisted of 50 euthyroid subjects seen at outpatient clinics. All participants underwent office and 24-h ambulatory BP measurement.
resultsBP monitoring revealed a higher prevalence of MH both in s-HYPO (26.3 %) and in o-HYPO (15.4 %) than in euthyroid subjects (10 %, p = 0.05); true hypertension also was more frequent in o-HYPO (11.5 %) and s-HYPO (10.5 %) than in controls (8 %, p = 0.03). The odds ratio for hypertension versus normotension confirmed a significantly increased risk of MH in hypothyroid patients versus euthyroid subjects (3.29, 1.08-10.08; p = 0.02). In a subgroup of patients reevaluated after restoration of euthyroidism, an improvement of BP profile was observed, especially in s-HYPO subgroup, with a decreased prevalence of MH (from 25 to 10.7 %) and true hypertension (from 10.7 to 3.4 %).
conclusionsHypothyroidism may be an important predictor of higher BP values, with an increased risk of MH. Because MH is a cardiovascular risk and can be reversed by thyroid hormone replacement, its presence should represent an indication for thyroid hormone replacement therapy also in patients with s-HYPO.
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