Evidence map›Paper›PMID 27193035›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Aging-related alterations in eNOS and nNOS responsiveness and smooth muscle reactivity of murine basilar arteries are modulated by apocynin and phosphorylation of myosin phosphatase targeting subunit-1.

Lubomir T Lubomirov, Symeon Papadopoulos, Sandra Pütz, Johannes Welter, Tim Klöckener, Kathrin Weckmüller, Mostafa A Ardestani, Dilyana Filipova, Doris Metzler, Harald Metzner and 5 more

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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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  8. mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Lubomir T Lubomirov1 Institute of Vegetative Physiology, University of Cologne, Germany.
Symeon Papadopoulos1 Institute of Vegetative Physiology, University of Cologne, Germany.
Sandra Pütz1 Institute of Vegetative Physiology, University of Cologne, Germany.
Johannes Welter1 Institute of Vegetative Physiology, University of Cologne, Germany.
Tim Klöckener2 Institute for Genetics, University of Cologne, Germany.
Kathrin Weckmüller1 Institute of Vegetative Physiology, University of Cologne, Germany.
Mostafa A Ardestani1 Institute of Vegetative Physiology, University of Cologne, Germany.
Dilyana Filipova1 Institute of Vegetative Physiology, University of Cologne, Germany.
Doris Metzler1 Institute of Vegetative Physiology, University of Cologne, Germany.
Harald Metzner1 Institute of Vegetative Physiology, University of Cologne, Germany.
Jürgen Staszewski1 Institute of Vegetative Physiology, University of Cologne, Germany.
Stefan Zittrich1 Institute of Vegetative Physiology, University of Cologne, Germany.
Hristo Gagov3 Faculty of Biology, Sofia University St. Kliment Ohridski, Sofia, Bulgaria.
Mechthild M Schroeter1 Institute of Vegetative Physiology, University of Cologne, Germany.
Gabriele Pfitzer1 Institute of Vegetative Physiology, University of Cologne, Germany.
University of Cologne · DESofia University "St. Kliment Ohridski" · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging causes major alterations of all components of the neurovascular unit and compromises brain blood supply. Here, we tested how aging affects vascular reactivity in basilar arteries from young (<10 weeks; y-BA), old (>22 months; o-BA) and old (>22 months) heterozygous MYPT1-T-696A/+ knock-in mice. In isometrically mounted o-BA, media thickness was increased by ∼10% while the passive length tension relations were not altered. Endothelial denudation or pan-NOS inhibition (100 µmol/L L-NAME) increased the basal tone by 11% in y-BA and 23% in o-BA, while inhibition of nNOS (1 µmol/L L-NPA) induced ∼10% increase in both ages. eNOS expression was ∼2-fold higher in o-BA. In o-BA, U46619-induced force was augmented (pEC

Indexed as

AgingAcetophenonesAnimalsBasilar ArteryEnzyme InhibitorsMiceMuscle, Smooth, VascularMyosin-Light-Chain PhosphataseNitric Oxide Synthase Type INitric Oxide Synthase Type IIIPhosphorylationProtein SubunitsVasoconstrictionAcetophenonesacetovanilloneEnzyme InhibitorsMyosin-Light-Chain PhosphataseNitric Oxide Synthase Type INitric Oxide Synthase Type IIINos1 protein, mouseNos3 protein, mouseProtein Subunitsactin dynamicsAgingbasilar arteryMYPT1-T696 gene mutationneurovascular uncouplingvascular hypercontractility

Identifiers

PMID27193035
PMCPMC5363478
OpenAlexW2407462864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.