ArticleScientific reports2016
Intraindividual dynamics of transcriptome and genome-wide stability of DNA methylation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration.Aging cell · 2026Review
- Examining saliva proteomic dynamics in mitochondrial diseases from a perspective of intrinsic health.Scientific reports · 2025Article
- Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes.Antibiotics (Basel, Switzerland) · 2023Article
- A methylation clock model of mild SARS-CoV-2 infection provides insight into immune dysregulation.Molecular systems biology · 2023Article
- Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder.Molecular psychiatry · 2023Review
- Evaluation of short-term epigenetic age fluctuation.Clinical epigenetics · 2022Article
- Genome-wide locus-specific DNA methylation repatterning may facilitate rapid evolution of mercury resistance in rice.Genes & genomics · 2022Article
- Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics.Clinical epigenetics · 2021Article
- Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging.Scientific reports · 2021Article
- Depression and suicide risk prediction models using blood-derived multi-omics data.Translational psychiatry · 2019Article
- iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation.Human genome variation · 2018Article
- Maternal Pregravid Obesity Remodels the DNA Methylation Landscape of Cord Blood Monocytes Disrupting Their Inflammatory Program.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies.NPJ genomic medicine · 2017Article
- Bioinformatics and Drug Discovery.Current topics in medicinal chemistry · 2017Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytosine methylation at CpG dinucleotides is an epigenetic mechanism that affects the gene expression profiles responsible for the functional differences in various cells and tissues. Although gene expression patterns are dynamically altered in response to various stimuli, the intraindividual dynamics of DNA methylation in human cells are yet to be fully understood. Here, we investigated the extent to which DNA methylation contributes to the dynamics of gene expression by collecting 24 blood samples from two individuals over a period of 3 months. Transcriptome and methylome association analyses revealed that only ~2% of dynamic changes in gene expression could be explained by the intraindividual variation of DNA methylation levels in peripheral blood mononuclear cells and purified monocytes. These results showed that DNA methylation levels remain stable for at least several months, suggesting that disease-associated DNA methylation markers are useful for estimating the risk of disease manifestation.
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