Evidence map›Paper›PMID 27192696›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2016

Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance.

Albert Shieh, Rene F Chun, Christina Ma, Sten Witzel, Briana Meyer, Brandon Rafison, Leon Swinkels, Tonnie Huijs, Sam Pepkowitz, Brett Holmquist and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Trial
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  8. High-Dose Vitamin DJPEN. Journal of parenteral and enteral nutrition · 2018
    Trial
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  10. Trial
  11. Article
  12. Article
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  15. Review
  16. Article
  17. Article
  18. Associations between Serum 25-Hydroxyvitamin D Levels and Health-Related Quality-of-Life Measures in Patients with Breast Cancer: A Longitudinal Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Albert ShiehDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Rene F ChunDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Christina MaDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Sten WitzelDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Briana MeyerDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Brandon RafisonDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Leon SwinkelsDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Tonnie HuijsDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Sam PepkowitzDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Brett HolmquistDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Martin HewisonDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
John S AdamsDepartment of Medicine, Division of Geriatrics (A.S.), and Department of Orthopaedic Surgery (R.F.C., S.W., B.M., B.R., J.S.A.), University of California, Los Angeles, Los Angeles, California 90095; David Geffen School of Medicine (C.M.), Los Angeles, California 90095; Future Diagnostics (L.S., T.H.), 6603 BN Wijchen, The Netherlands; Esoterix, Inc. (S.P., B.H.), Austin, Texas 78744; and Institute of Metabolism and Systems Research (M.H.), The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
University of California, Los Angeles · USFuture Diagnostics (Netherlands) · NLUniversity of Birmingham · GB

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Vitamin D Metabolism in LeprosyP50AR063020 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S · 2012 to 2016
$7.8M
DBP and the bioavailability and function of vitamin DR01AR063910 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S, HEWISON, MARTIN · 2013 to 2017
$1.8M
NCATS NIH HHS UL1 TR000124NIAMS NIH HHS P50 AR063020NIAMS NIH HHS R01 AR063910
6 · The paper itself

Abstract

contextControversy persists over: 1) how best to restore low serum 25-hydroxyvitamin D (25D) levels (vitamin D2 [D2] vs vitamin D3 [D3]); 2) how best to define vitamin D status (total [protein-bound + free] vs free 25D); and 3) how best to assess the bioactivity of free 25D.

objectiveTo assess: 1) the effects of D2 vs D3 on serum total and free 25D; and 2) whether change in intact PTH (iPTH) is more strongly associated with change in total vs free 25D.

designParticipants previously enrolled in a D2 vs D3 trial were matched for age, body mass index, and race/ethnicity. Participants received 50 000 IU of D2 or D3 twice weekly for 5 weeks, followed by a 5-week equilibration period. Biochemical assessment was performed at baseline and at 10 weeks. SETTING AND

participantsThirty-eight adults (19 D2 and 19 D3) ≥18 years of age with baseline 25D levels <30 ng/mL were recruited from an academic ambulatory osteoporosis clinic. OUTCOME MEASURES: Serum measures were total 25D, free 25D (directly measured), 1,25-dihydroxyvitamin D, calcium, and iPTH. Urine measure was fasting calcium:creatinine ratio.

resultsBaseline total (22.2 ± 3.3 vs 23.3 ± 7.2 ng/mL; P = .5) and free (5.4 ± 0.8 vs 5.3 ± 1.7 pg/mL; P = .8) 25D levels were similar between D2 and D3 groups. Increases in total (+27.6 vs +12.2 ng/mL; P = .001) and free (+3.6 vs +6.2 pg/mL; P = .02) 25D levels were greater with D3 vs D2. Percentage change in iPTH was significantly associated with change in free (but not total) 25D, without and with adjustment for supplementation regimen, change in 1,25-dihydroxyvitamin D, and change in calcium.

conclusionsD3 increased total and free 25D levels to a greater extent than D2. Free 25D may be superior to total 25D as a marker of vitamin D bioactivity.

Indexed as

AdultAgedBiomarkersCalciumCase-Control StudiesCholecalciferolDose-Response Relationship, DrugErgocalciferolsHomeostasisHormone Replacement TherapyHumansMiddle AgedParathyroid HormoneVitamin DVitamin D Deficiency25-hydroxyvitamin DBiomarkersCalciumCholecalciferolErgocalciferolsParathyroid HormoneVitamin D

Identifiers

PMID27192696
PMCPMC4971338
OpenAlexW2406959653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.