Evidence map›Paper›PMID 27192177›Full record

ArticleNMR in biomedicine2017

Dentate nucleus iron deposition is a potential biomarker for tremor-dominant Parkinson's disease.

Naying He, Pei Huang, Huawei Ling, Jason Langley, Chunlei Liu, Bei Ding, Juan Huang, Hongmin Xu, Yong Zhang, Zhongping Zhang and 3 more

Open access · greenAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  11. Iron Deposition in Parkinson's Disease: A Mini-Review.Cellular and molecular neurobiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Naying HeDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pei HuangDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huawei LingDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jason LangleyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Chunlei LiuBrain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA.
Bei DingDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Juan HuangDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hongmin XuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yong ZhangMR Research, Ge Healthcare, Shanghai, China.
Zhongping ZhangMR Research, Ge Healthcare, Shanghai, China.
Xiaoping HuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Shengdi ChenDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fuhua YanDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ruijin Hospital · CNShanghai Jiao Tong University · CNUnited Imaging Healthcare (China) · CNDuke Medical Center · USGeorgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

Ultra-Resolution Imaging of Brain Circuitry and its Development in Mental HealthR01MH096979 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIU, CHUNLEI · 2013 to 2017
$1.8M
Susceptibility MRI as a marker for diagnosis and clinical disability in MSR01NS079653 · NINDS · DUKE UNIVERSITY · PI LIU, CHUNLEI · 2014 to 2015
$460k
NIMH NIH HHS R01 MH096979NINDS NIH HHS R01 NS079653
6 · The paper itself

Abstract

Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with variable clinicopathologic phenotypes and underlying neuropathologic mechanisms. Each clinical phenotype has a unique set of motor symptoms. Tremor is the most frequent initial motor symptom of PD and is the most difficult symptom to treat. The dentate nucleus (DN) is a deep iron-rich nucleus in the cerebellum and may be involved in PD tremor. In this study, we test the hypothesis that DN iron may be elevated in tremor-dominant PD patients using quantitative susceptibility mapping. Forty-three patients with PD [19 tremor dominant (TD)/24 akinetic rigidity (AR) dominant] and 48 healthy gender- and age-matched controls were recruited. Multi-echo gradient echo data were collected for each subject on a 3.0-T MR system. Inter-group susceptibility differences in the bilateral DN were investigated and correlations of clinical features with susceptibility were also examined. In contrast with the AR-dominant group, the TD group was found to have increased susceptibility in the bilateral DN when compared with healthy controls. In addition, susceptibility was positively correlated with tremor score in drug-naive PD patients. These findings indicate that iron load within the DN may make an important contribution to motor phenotypes in PD. Moreover, our results suggest that TD and AR-dominant phenotypes of PD can be differentiated on the basis of the susceptibility of the DN, at least at the group level. Copyright © 2016 John Wiley & Sons, Ltd.

Indexed as

BiomarkersCerebellar NucleiDiffusion Tensor ImagingFeasibility StudiesFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedMolecular ImagingParkinson DiseaseReproducibility of ResultsSensitivity and SpecificityTissue DistributionTremorBiomarkersakinetic rigidity-dominant phenotypeiron depositionParkinson's diseasequantitative susceptibility mappingtremor-dominant phenotype

Identifiers

PMID27192177
PMCPMC4906439
OpenAlexW2404085916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.