Evidence map›Paper›PMID 27192175›Full record

ArticleRetinal cases & brief reports

PERIPHERAL RETINOPATHY ASSOCIATED WITH APLASTIC ANEMIA.

Tatyana I Metelitsina, Veeral S Sheth, Shuchi B Patel, Michael A Grassi

Open access · greenAbstract readCase Reports
In one paragraph

Article in Retinal cases & brief reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tatyana I Metelitsina*Retina Consultants Ltd, Des Plaines, Illinois; †University Retina and Macula Associates, Oak Forest, Illinois; ‡Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois; and §Department of Ophthalmology, Loyola Medical Center, Maywood, Illinois. Metelitsina is now at Eye Care Specialists, LLC, Cape Girardeau, Missouri. Dr. Grassi is now at Grassi Retina MD SC, Naperville, Illinois.
Veeral S Sheth
Shuchi B Patel
Michael A Grassi
California Retina Consultants · USUniversity of Illinois Chicago · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
Role of Leukocyte-endothelial Adhesion in Diabetic RetinopathyR01EY023644 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GRASSI, MICHAEL A. · 2015 to 2019
$1.9M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY023644
6 · The paper itself

Abstract

purposeTo report a case of severe, bilateral, rapidly progressing peripheral retinal nonperfusion associated with underlying aplastic anemia.

methodsAn interventional case report.

resultsA 4-year-old girl presented with decreased visual acuity. On clinical examination, she was found to have a RAPD, elevated intraocular pressure, 360° rubeosis, vitreous hemorrhage, severe exudative retinal detachment, and telangiectasia with severe peripheral retinal nonperfusion. Laboratory workup was significant for pancytopenia, and a bone marrow biopsy showed extreme hypocellularity with no malignant cells. The patient was diagnosed with primary aplastic anemia. She developed dramatic progression of retinal nonperfusion in the left eye, as well as in the fellow right eye. This bilateral retinopathy was poorly responsive to aggressive management, which included laser photocoagulation and intravitreal injections of anti-vascular endothelial growth factor medications.

conclusionAsymmetric, bilateral quickly progressing peripheral retinal ischemia, in conjunction with pancytopenia and otherwise negative workup may be related to underlying bone marrow failure and aplastic anemia.

Indexed as

Anemia, AplasticChild, PreschoolDiagnosis, DifferentialFemaleHumansRetinal Diseases

Identifiers

PMID27192175
PMCPMC5114174
OpenAlexW2406664279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.